Gokmen, Selma SuerKazezoglu, CemalAygit, A. CemalYildiz, ReyhanCakir, BeyhanTure, MevlutGulen, Sendogan2024-06-122024-06-1220100250-46851303-829Xhttps://hdl.handle.net/20.500.14551/18722Objectives: Arginase activity and ornithine concentration have been shown to be elevated in experimentally-induced benign tumors in mice. The aim of the study is to investigate arginase activity and ornithine concentration in human benign and malignant skin tumors and to evaluate their role for prognosis of skin tumors. Patients and Methods: We have investigated arginase activity and ornithine concentration in supernatant of homogenates of benign tumors (nevus) of the skin from 13 patients and of malignant tumors (squamous cell or basal cell carcinomas) from 29 patients. Total arginase activity, ornithine and total protein concentration in supernatant were determined by the methods of Geyer, Chinard and Lowry, respectively. Results: Arginase activity (p=0.006) and ornithine concentration (p=0.007) in nevus were significantly higher than in adjacent normal tissue. There was no significant difference between their levels in basal cell carcinoma and in nevus (p>0.05). There was no significant difference between ornithine concentration in squamous cell carcinoma and in nevus (p>0.05). However, arginase activity in this carcinoma was significantly higher than in nevus (p=0.018). Conclusion: The significant difference between tissue arginase activities in squamous cell carcinoma and in nevus indicates that determination of arginase activity could be useful for prognosis of skin tumors.eninfo:eu-repo/semantics/closedAccessArginaseOrnithineNevusSquamous Cell CarcinomaBasal Cell CarcinomaNitric-OxideProstatic-CarcinomaCancerHyperplasiaExpressionTissueDecarboxylaseMetabolismPolyaminesInductionArticle354319324Q4WOS:0002856488000062-s2.0-78651410987Q4