Kilic-Okman, TulayYardim, TurgutGucer, FatihAltaner, SemsiYuce, M. Ali2024-06-122024-06-1220080932-00671432-0711https://doi.org/10.1007/s00404-007-0535-xhttps://hdl.handle.net/20.500.14551/23122Background Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Patients with PJS have increased risk for gastrointestinal, breast, and female genital tract cancers. Case Multiple genital tract cancers in a 34-year-old woman with PJS are described. The patient, who was admitted to our department with severe vaginal bleeding, was performed right salpingo-oophorectomy because of pure gonadoblastoma in 1996. In 2003, concomitant to cervical carcinoma, breast cancer was diagnosed. Patient underwent left modified radical mastectomy due to the invasive papillary carcinoma. The patient received six cycles combination chemotherapy and radiation therapy because of stage IIIB cervical cancer. Conclusion(s) This is the first case report presenting PJS associated with multiple genital tract tumors including ovarian gonadoblastoma in literature. The clinical significance of these tumors in PJS patients has been reviewed.en10.1007/s00404-007-0535-xinfo:eu-repo/semantics/closedAccessPeutz-Jeghers SyndromeGonadoblastomaBreastCervixCancerSex Cord TumorAnnular TubulesArticle27817577Q4WOS:0002562633000142-s2.0-4444917455218193442Q2