Kaya, MÇermik, TFÜstün, FSen, SBerkarda, S2024-06-122024-06-1220020914-7187https://doi.org/10.1007/BF02993714https://hdl.handle.net/20.500.14551/19816Purpose: The aim of this study was to evaluate the changes in salivary gland function in patients with chronic renal failure (CRF) undergoing hemodialysis. Methods: The group consisted of 23 patients with CRF (13 female, 10 males mean age: 40 +/- 13 yr) and 14 healthy control subjects (mean age: 40 +/- 13 yr). All underwent dynamic salivary gland scintigraphy with gustatory stimulation, After intravenous administration of Tc-99m pertechnetate, first. perfusion images at 2 seconds per frame were acquired for I minute, then dynamic images at 1 minute per frame were acquired for 45 minutes, At 30 minutes after injection, 10 ml lemon juice was given for 15 minutes as a gustatory stimulus. We obtained time-activity curves derived from regions of interest centered over the four major salivary glands. The following functional indices were calculated for each gland: the time of maximum radioactivity (T-max) for the prestimulated period, the time of minimum radioactivity (T-min), as an indicator of velocity of secretion after stimulation, and the Lem E-5% value as an indicator of the secretion function. Results: When the patients with CRF undergoing hemodialysis were compared to the controls, there were statistically significant differences in T-max, T-min and Lem E5% values for bilateral parotid glands, and Train values for bilateral submandibular glands (p < 0.05), there were no statistically significant differences in Tmax and Lem E5% values for bilateral submandibular glands. There were also significant differences in T-max and Lem E5% values for bilateral parotid glands between mild oral problems and severe oral problems in patients with CRF (undergoing hemodialysis). Conclusion: In this study, prolonged T-max and T-min values, and decreased Lem E5% values for parotid glands and prolonged T-min values for submandibular glands on salivary scintigraphy pointed out decreased parenchymatous and excretory function in patients with CRF undergoing hemodialysis.en10.1007/BF02993714info:eu-repo/semantics/closedAccessChronic Renal FailureSalivary FunctionScintigraphyGland ScintigraphySjogrens-SyndromeStageDiseaseArticle162117120Q4WOS:0001755670000052-s2.0-003600134812043905Q2