Aktoz, TevfikKanter, MehmetUz, Yesim HulyaAktas, CevatErboga, MustafaAtakan, Irfan Huseyin2024-06-122024-06-1220122146-31232146-3131https://doi.org/10.5152/balkanmedj.2011.014https://hdl.handle.net/20.500.14551/19435Objective: The aim of the present study was to examine the protective effect of quercetine (QE) against cadmium (Cd)-induced renal toxicity. Material and Methods: A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated and Cd-treated with QE; each group containing 8 animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the dose of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in the QE treated groups were given QE (15 mg/kg body weight) once a day intraperitoneally starting 2 days prior to Cd injection during the study period. Results: The renal histology in Cd-treated rats showed mesangial expansion, thickening of capsular basement membranes, glomerular basement membranes and tubular basement membranes, characterized by an increase in periodic acid Schiff (PAS)-positive areas as compared with control animals. With the QE treatment, despite the presence of only a few swollen glomeruli, we noticed a marked protection of renal structure when compared with the Cd-treated rats. Furthermore, QE pretreatment resulted in increased proliferating cell nuclear antigen (PCNA) immunoreactivity and decreased the activity of Terminal Transferase dUTP Nick End Labeling (TUNEL). Conclusion: These findings suggest that QE may attenuate Cd-induced renal toxicity.en10.5152/balkanmedj.2011.014info:eu-repo/semantics/openAccessCadmiumImmunohistochemistryQuercetinRenal ToxicityTUNELLipid-PeroxidationUltrastructural-ChangesCell-DeathKidneyNephrotoxicityIntoxicationExposureSeleniumMetallothioneinRegenerationArticle2915661Q4WOS:0003036184000112-s2.0-84862067233Q3