Kapicibasi, Hasan OguzKiraz, Hasan AliDemir, Emin TuncAdali, YasemenElmas, Sait2024-06-122024-06-1220200102-86501678-2674https://doi.org/10.1590/s0102-865020200060000004https://hdl.handle.net/20.500.14551/22236Purpose: This experimental sepsis model created with Escherichia coil aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1st group was treated with cefepime, the 2nd and 3rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. Results: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). Conclusion: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters.en10.1590/s0102-865020200060000004info:eu-repo/semantics/openAccessLungOzoneSepsisRatsAcute Lung InjuryAnimal-ModelOxygenManagementMortalityArticle356Q4WOS:0005505936000012-s2.0-8508788154932667585Q3