Bayram, S.Kizilay, G.Topcu-Tarladacalisir, Y.2024-06-122024-06-1220161052-02951473-7760https://doi.org/10.3109/10520295.2015.1129556https://hdl.handle.net/20.500.14551/20444We investigated the role of the Fas/Fas ligand (FasL) signaling pathway in diabetic male infertility. Male rats were divided into two groups: a control group and a streptozotocin induced diabetic group. Thirty days after induction of diabetes, samples of testes were harvested and fixed in 10% formalin for light microscopy. Germ cell apoptosis was determined using the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate in situ nick end-labeling (TUNEL) and immunostaining of caspase 8 and active caspase 3. We also investigated the expressions of Fas and FasL using immunohistochemistry. Streptozotocin-induced diabetes caused severe histopathological damage and increased apoptotic tubule and apoptotic cell indices, caspase 8 and caspase 3 expressions, and Fas and FasL-immunopositive cells in the rat testes. We suggest that the Fas/FasL signaling pathway may play a role in male infertility caused by diabetes.en10.3109/10520295.2015.1129556info:eu-repo/semantics/closedAccessDiabetes MellitusTestisRatCaspaseCaspase 8FaslImmunohistochemistryFas3Germ-Cell ApoptosisFas SystemUp-RegulationInvolvementActivationExpressionIncreasesMechanismEthanolDamageArticle913204211Q4WOS:0003728984000062-s2.0-8496121288326960002Q2