Varol, FusunUzunoglu, RenginarErbas, HakanSut, NecdetSayin, Cenk2024-06-122024-06-1220151076-02961938-2723https://doi.org/10.1177/1076029613498816https://hdl.handle.net/20.500.14551/23294Backgound/Aim: Preeclampsia (PE) is a multisystem disease resulting in high maternal-fetal morbidity and mortality. The aim of the study was to investigate antiangiogenesis-associated alterations in antiapoptotic and antioxidative proteins in PE. Method: Of the 46 patients with PE, 25 (54.3%) were with gestational hypertension (GH), 12 (26%) were with mild, and 9 (19.5%) were with severe PE. The serum levels of vascular endothelial growth factor receptor 1 (VEGFR-1), heme oxygenase 1 (HO-1), and B-cell lymphoma/leukemia (Bcl-2) levels were measured by enzyme-linked immunosorbent assay. Results: In the severe PE group, the VEGFR-1 serum levels (27.3 16.8 vs 13.3 +/- 10.7 ng/mL, P = .023) were higher, but the Bcl-2 levels (1.5 +/- 0.2 vs 2.1 +/- 1.7 ng/mL, P = .047) were lower than the levels in the GH-mild PE group (P = .047). Also, VEGFR-1/Bcl-2 ratio in the severe PE group was significantly higher (P = .003) than the ratio in the GH-mild PE group. Conclusion: The Bcl-2 and HO-1 proteins seem to have important roles in the antiangiogenic environment of preeclampsia.en10.1177/1076029613498816info:eu-repo/semantics/closedAccessPreeclampsiaVEGFR-1Bcl-2HO-1Endothelial Growth-FactorHeme Oxygenase-1InductionExpressionReceptorArticle213285288Q3WOS:0003504928000142-s2.0-8492490848023925400Q2