Pamuk, Guelsuem EmelPamuk, Omer NuriOrum, HueseyinDemir, MuzafferTurgut, BurhanCakir, Necati2024-06-122024-06-1220100957-52351473-5733https://doi.org/10.1097/MBC.0b013e328330bdc4https://hdl.handle.net/20.500.14551/19011We determined platelet-leucocyte complexes, which play roles in the thrombosis-inflammation relationship, in Behget's disease patients with and without major vascular involvement (MVI) and in healthy controls. We included 36 Behget's disease patients (22 male, 14 female, mean age: 34.4 +/- 8.3 years) and 20 healthy individuals (14 male, six female, mean age: 31.8 +/- 4.4 years). Whole blood count, CRIP and ESR were determined in both groups. Clinical data about the patients were obtained from medical charts. Individuals with hypertension, diabetes, coronary artery disease, and smokers were excluded. Behcet's disease patients with MVI were taken as a separate group (8 male, 5 female, mean age: 37 +/- 8 years). MVI was defined as the presence of pulmonary arterial aneurysm, deep venous thrombosis, vena cava inferior or superior thrombosis, or venous sinus thrombosis. Flow cytometry was used to determine platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), basal and adenosine diphosphate (ADP)-stimulated platelet CD62P expression. Behget's disease patients with MVI had significantly higher PNC than Behcet's disease patients without MVI and healthy controls (P values=0.01). PMC levels in Behcet's disease patients with MVI were significantly higher than in healthy controls (P=0.01). The groups were similar in basal and ADP-stimulated platelet CD62P expression (P values >0.05). Basal and ADP-stimulated CD62P expression, PMC and PNC were not significantly different between active Behget's disease versus inactive Behget's disease patients. The evaluated parameters were similar in Behget's disease patients with and without uveitis, and pathergy-positive and pathergy-negative groups. Our results might suggest that the formation of PMC and PNC might play a role in thrombosis and MVI of Behget's disease. Blood Coagul Fibrinolysis 21:113-117 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en10.1097/MBC.0b013e328330bdc4info:eu-repo/semantics/closedAccessBehcet's DiseasePlatelet-Monocyte ComplexesPlatelet-Neutrophil ComplexesP-Selectin (CD62P)Flow-CytometryCardiopulmonary BypassActivated PlateletsTissue FactorAdhesionNeutrophilArticle212113117Q4WOS:0002745136000022-s2.0-7644910284620135752Q3