Yüce, M. AliKaplan, Balkanlı PetekGüçer, FatihSayın, N. CenkYüksel, Mahmut2024-06-122024-06-1220051300-47512602-4918https://search.trdizin.gov.tr/yayin/detay/61618https://hdl.handle.net/20.500.14551/15416OBJECTIVE: To assess the effect of estrogen, estrogen combined with progesterone or tibolon on serum total homocysteine levels, an independent risk factor for cardiovascular disorders, in postmenopausal women. STUDY DESIGN: In a randomised order, healthy, non-smoking postmenopausal women were included in the study. They received either conjugated equine estrogen 0.625 mg alone (CEE, n=16), CEE combined with medroxyprogesterone actate 5mg (CEE/MPA, n=20) or tibolon 2.5 mg (n=10). Treatments were given for three treatment cycles of 28 days (3 months). Plasma levels of homocysteine were measured at baseline and 3 months after the start of the study. RESULTS: There was no statistically significant change in plasma homocysteine levels in the only estrogen-treated group, sequentially combined CEE plus MPA-treated group and tibolone group. CONCLUCION: Neither CEE alone nor combination of CEE with MPA or tibolone treatment causes significant changes in plasma homocysteine levels in postmenopausal women with normal baseline homocysteine levels.eninfo:eu-repo/semantics/openAccessArticle11318919361618