Budak, MetinYalcin, OmerUsta, UfukTokuc, Burcu2024-06-122024-06-1220170970-938X0976-1683https://hdl.handle.net/20.500.14551/18462Angiomyolipomas are tumors of the kidneys which are often benign in character with a potential for malignant transformation. The benign-malign distinction in these tumors can be made only with clinical follow-up as they exhibit the same microscopic appearance. In the present study, immunohistochemical investigation has been performed for p53, p21(WAF1), PCNA and bcl-2, which may be markers for the histological distinction of benign and malignant cases. The p53, p21WAF1, PCNA and bcl-2 investigations in 10 tumor tissues with AML revealed significantly higher p53 positivity in 3 patients. The clinical follow-up of these three patients showed malignant progression. In conclusion, we believe that p53 positivity may be an appropriate marker for the benign-malign distinction in AML tumors.eninfo:eu-repo/semantics/closedAccessAngiomyolipomasP53RenalEpithelioid AngiomyolipomaKidneySpectrumArticle281046964702N/AWOS:0004073241000792-s2.0-85020900937N/A