Zaim, OmerAghatabay, Naz MohammedGurbuz, Mustafa UlviBaydar, CaglarDulger, Basaran2024-06-122024-06-1220141388-31271573-1111https://doi.org/10.1007/s10847-012-0282-xhttps://hdl.handle.net/20.500.14551/18572Five novel [1+1] condensed cycloheterophane peptides were synthesized via reaction of pyridine-2,6-bis(2-aminothiophenoxymethyl) with several diacid chlorides: glutaryl dichloride, adipoyl dichloride, 2,2'-thiodiacetyl chloride, dithiodiglycoloyl chloride and 3,3'-thiodipropionoyl chloride combinations (L-1-L-5). The compounds were characterized by elemental analyses, mass, FT-IR, H-1, and C-13 NMR spectral data. The antimicrobial activities of the compounds were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration dilution method, against several bacteria and yeast cultures. The results were compared with those of commercial antibiotic and antifungal agents. Structure activity relationships were also discussed. Permeability of compound L-5 against Na+ and K+ were also investigated.en10.1007/s10847-012-0282-xinfo:eu-repo/semantics/closedAccessAntimicrobialCycloheterophaneDiffusionIon TransportPermeabilityThia Macrocyclic-CompoundsPhane NomenclatureFt-IrComplexationDerivativesCytotoxicityBindingRamanArticle781-4151159Q2WOS:0003344967000152-s2.0-84893814896Q3