Inal, Mehmet TuranMemis, DilekSut, Necdet2024-06-122024-06-1220102146-64162147-267Xhttps://hdl.handle.net/20.500.14551/18948Objective: Sepsis is frequently seen in intensive care unit patients, representing an important cause of mortality. Prediction of prognosis in patients with sepsis is of particular importance. We investigated the relationship of plasma clearance rate of indocyanine green (ICG-PDR) and Pitt bacteremia score with prognosis in sepsis. Materials and methods: We retrospectively evaluated 100 patients whose ICG-PDR values were measured noninvasively with the LiMON system and Pitt bacteremia scores were determined within the first 24 hours of admission to intensive care unit. All the patients were diagnosed with sepsis before receiving intensive care. ICG-PDR values and Pitt bacteremia scores were compared between patients who died (n=48; mean age 62.4 16.5 years) or survived (n=52; mean age 60.8 +/- 18.2 years) during intensive care stay. Results: Compared to survivors, the mean ICG-PDR was significantly lower (21.1 +/- 5.4%/min vs. 13.9 +/- 6.4 %min; p<0.001) and the mean Pitt bacteremia score was significantly higher (4.9 +/- 2.0 vs. 10.2 +/- 1.7; p=0.000) in patents who died during intensive care treatment. In ROC analysis, the area under the curve was 0.819 for ICG-PDR, and 0.955 for Pitt bacteremia score. The optimal cut-off points for ICG-PDR and Pitt bacteremia score were 14.8%/min and 7, respectively. ICG-PDR and Pitt bacteremia score predicted mortality with a sensitivity of 75% and 97.9%, and specificity of 92.3% and 92.3%, respectively. Conclusion: Our findings show that both ICG-PDR and Pitt bacteremia score are effective markers in predicting survival of patients with sepsis and can be used in the evaluation of disease severity.trinfo:eu-repo/semantics/closedAccessBacteremia/DiagnosisCritical Illness/MortalityHealth Status IndicatorsIndocyanine Green/Diagnostic UseIntensive Care Units/MortalityMetabolic Clearance RatePrognosisSensitivity And SpecificitySepsis/MortalityArticle8115N/AWOS:000219355700001