Guclu, HandeGorgulu, YaseminGurlu, Vuslat PelitliCinar, Rugul KoseOzal, Sadik AltanCaliyurt, Okan2024-06-122024-06-1220180271-36831460-2202https://doi.org/10.1080/02713683.2017.1420198https://hdl.handle.net/20.500.14551/22260Purpose: To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs.Methods: The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT). The Mann-Whitney U test was used to compare the patients' group with the age- and gender-matched control group. Pearson correlation analyses were also performed to assess the relationships between macular thickness, GCC thickness, RNFL thickness, and the duration of SSRI usage.Results: The mean duration of SSRI usage was 29.9627.19 (range 6-120) months. The foveal thickness was 253.48 +/- 22.77 mu m in the patients' group and 266.60 +/- 20.64 mu m in the control group; the difference between the groups was statistically significant. In addition, the perifoveal GCC thickness in the inferonasal and inferotemporal quadrant were significantly smaller thinner in the patient group (Mann-Whitney U test, p=0.021and p=0.013, respectively).Conclusions: Our results suggest a relation between SSRIs and decreased retinal GCC thickness and RNFL thickness. Future long-term prospective studies should elucidate the actual effect of SSRIs on GCC and RNFL thickness.en10.1080/02713683.2017.1420198info:eu-repo/semantics/closedAccessMacular ThicknessGanglion Cell Complex ThicknessRetinal Nerve Fiber Layer ThicknessSelective Serotonin Reuptake InhibitorsAngle-Closure GlaucomaOptical Coherence TomographyMajor Depressive DisorderFluoxetineParoxetineRetinopathyPatientAntidepressantsChloroquineCitalopramArticle434547552Q3WOS:0004275520000182-s2.0-8503954540029283680Q2