Celik, MehmetOzcelik, SerhatBas, SuleymanSariaydin, MehmetOzcelik, MelikeGozu, Hulya2024-06-122024-06-1220212359-39972359-4292https://doi.org/10.20945/2359-3997000000399https://hdl.handle.net/20.500.14551/21720Objective: We aimed to investigate the role of testosterone to estradiol ratio in predicting the effectiveness of human chorionic gonadotropin and testosterone treatments in male hypogonadism. Materials and methods:Thirty-six male patients with hypogonadotropic hypogonadism were included in the study. Seventeen (47.2%) patients received weekly recombinant human choriogonadotropin alpha (hCG) treatment (group-1) and 19 (52.8%) received testosterone replacement therapy (T treatment) every 21 days (group-2). Under these treatments, adequate frequency of morning erection (0_3/week), testosterone to estradiol ratio (T/E), and testicular volume changes were analyzed. Results: The mean age of the patients was 28.5 +/- 8.7 years. When the frequency of morning erection (0_3/week) was specified as adequate, the cut-off value for effective T/E ratio was found to be 12.0 (sensitivity 93.8%, specificity 90.0%). There was no significant difference between the treatment groups in terms of total testosterone levels, T/E ratio, or frequency of morning erections (0_3/week) (p 0.05). However, there was a statistically significant difference between the groups in terms of median left-right testicular volume in favor of group-1 (p < 0,05). Conclusion: In patients with hypogonadism who are under treatment, elevated estradiol-induced erectile dysfunction symptoms may persist even if serum testosterone levels are normal. Testosterone to estradiol ratio can be used as a predictive value in the effective treatment of hypogonadotropic hypogonadism with hCG and T. Arch Endocrinol Metab. 2021;65(5):617-24en10.20945/2359-3997000000399info:eu-repo/semantics/openAccessHypogonadismTestosterone To Estradiol RatioMorning ErectionErectile DysfunctionHypogonadotropic HypogonadismPenile TumescenceMenDiagnosisTherapyHormoneArticle655617624Q4WOS:0007194620000122-s2.0-8512194275434591405Q3