Tay, Naime FundaDuran, MuratKayagil, IsmailYurttas, LeylaGoger, GamzeGoger, FatihDemirci, Fatih2024-06-122024-06-1220221984-82502175-9790https://doi.org/10.1590/s2175-97902022e191026https://hdl.handle.net/20.500.14551/24402In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 mu g/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.en10.1590/s2175-97902022e191026info:eu-repo/semantics/openAccessTriazoleThiazolePyridineAntimicrobial ActivityAntioxidant ActivityDPPH Radical Scavenging1,2,4-Triazole DerivativesBiological EvaluationIn-VitroMolecular DockingHybrid MoleculesLinked BisAntifungalAntitumorAntibacterialAgentsArticle58Q4WOS:0008284709000012-s2.0-85129728009Q2