Karaca, TuranDemirtas, SelimKaraboga, IhsanAyvaz, Suleyman2024-06-122024-06-1220151300-01441303-6165https://doi.org/10.3906/sag-1311-103https://search.trdizin.gov.tr/yayin/detay/211802https://hdl.handle.net/20.500.14551/20450Background/aim: To examine the effects of royal jelly (RJ) on testicular damage in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Eighteen adult Wistar albino rats were used, 6 in each of the 3 treatment groups: Group A: control, Group B: STZ-induced diabetes (untreated), Group C: STZ-induced diabetes plus RJ (400 mg/kg daily for 4 weeks). Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Four weeks after the onset of diabetes, testicular apoptotic cell death was examined using immunohistochemical staining for caspase-3 and Ki67 staining for localization of proliferative cells. Results: Compared with the control, the body and testicular weights of the RJ-treated and untreated diabetic rats were decreased (P < 0.05). The histopathological examination showed a significant increase in degenerative changes in the seminiferous tubules and in spermatogenesis of the STZ-treated rats. In contrast, the RJ treatment group showed near-normal morphology, in addition to an increased intensity of immunohistochemical staining for Ki67-positive cells. Conclusion: Diabetes induced a significant increase in testicular apoptotic cell death (caspase-3-positive cells). Caspase-3-positive cells were significantly decreased in the STZ plus RJ-treated group compared with the untreated STZ-induced diabetic group (P < 0.05).en10.3906/sag-1311-103info:eu-repo/semantics/openAccessDiabetesTestesApoptosisProliferationRoyal JellyReproductive FunctionApoptosisArticle4512732Q4WOS:0003478400000052-s2.0-8492000075225790526Q3211802