Arikan, M. G.Soyluoglu, S.Korkmaz, U.Tastekin, E.Elboga, U.Arda, E.2024-06-122024-06-1220242253-654Xhttps://doi.org/10.1016/j.remn.2024.01.001https://hdl.handle.net/20.500.14551/23379Objective: To evaluate the predictive potential of the maximum standardized uptake value (SUVmax) value of intraprostatic tumors derived from preoperative [Ga- 68 ]Ga-PSMA-I&T PET/CT (SUVT), and its ratios to SUVmax in the liver (SUVTLR) and parotid gland (SUVTPR) with respect to histopathological findings. Materials and methods: Data from patients who underwent radical prostatectomy (RP) for prostate cancer (PC) at our clinic between 2017-2020 were assessed. Patients with a secondary malignancy, a history of transurethral prostate resection, prior treatment for PC, or who received salvage RP were excluded. Whole -body images obtained using the same device, as per the guidelines, were reviewed by two nuclear medicine specialists with more than a decade of experience to reach a consensus for each lesion. The relationships between age, PSA, Prostate Volume, clinical T stage, biopsy International Society of Urological Pathology grade (ISUP), D'amico risk group, intraprostatic tumor volume (HPTV) identified in the final histopathological specimen review, HP-ISUP grade, seminal vesicle invasion (SVI), extracapsular invasion (ECI), positive surgical margine (PSM), SUVT, SUVTLR, and SUVTPR were analyzed. Results: The mean age of the 64 included patients was 64.1 +/- 5.3 y -o. A statistically significant correlation was found between SUVT, SUVTLR, SUVTPR values, and histopathologic stage parameters, such as biopsy ISUP, D'amico Risk Classification, HP-ISUP, HPTV ( P <.05). PSMATV, SUVT, and SUVTLR were statistically significant predictors of extracapsular invasion, while PSA, PSMATV, and SUVTLR were significant predictors of SVI ( P <.05). Conclusion: The standardized SUVT, SUVTLR, and SUVTPR values could be employed as noninvasive markers to assist in predicting postoperative histopathological findings, particularly ECI, SVI, and PSM.es10.1016/j.remn.2024.01.001info:eu-repo/semantics/closedAccessProstate Cancer[Ga-68]Ga-PSMA-I&T PET/CTSuvmaxHistopathologyPredictive PotentialIntraprostatic TumorProstatectomyIntraprostatic Tumor ExtentGleason ScorePsma ExpressionHigh-RiskCancerAccuracyMriInvasionAntigenMenArticle432100106N/AWOS:0012240391000012-s2.0-8518732000438331250Q3