The effect of a flavonoid fractions diosmin plus hesperidin on radiation-induced acute proctitis in a rat model

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dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.contributor.authorSezer, Atakan
dc.contributor.authorUsta, Ufuk
dc.contributor.authorKocak, Zafer
dc.contributor.authorYagci, Mehmet Ali
dc.date.accessioned2024-06-12T10:50:36Z
dc.date.available2024-06-12T10:50:36Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: To explore the protective effect of a flavonoid fractions diosmin + hesperidin (Daflon), against radiation-induced acute proctitis in an experimental rat model. Materials and Methods: Thirty four rats were divided into four groups. The rats in Group 1 received Daflon and underwent irradiation. The rats in Group 2 received no Daflon and underwent irradiation. The rats in Group 3 received Daflon and underwent sham irradiation. The rats in Group 4 received no Daflon and underwent sham irradiation. Daflon emulsion (100 mg/kg/day) was administered via an orogastric feeding tube to the rats in groups 1 and 3 starting from 1 day prior to irradiation until the euthanasia day (day 15 following irradiation). Radiation therapy was delivered on a cobalt-60 unit using a single fraction of 17.5 Gy defined at a depth of 1 cm through an anterior portal. Slides were examined by the same pathologist under a light microscope two times in a blinded manner. Results: When compared to group 2, the rats of Group 1 showed less glandular distortion and less mucosal inflammation with less infiltration of the crypt epithelia by the inflammatory cells (P < 0.001). A statistically significant increase in all parameters but muscular wall thickness was observed for the rats in Group 2 as compared to the group 3 and 4. Conclusions: Administration of a dose of 100 mg/kg/day of the diosmin + hesperidin resulted in decreased morphologic inflammatory changes. This drug may have protective effects against radiation-induced acute proctitis.en_US
dc.identifier.doi10.4103/0973-1482.82927
dc.identifier.endpage156en_US
dc.identifier.issn0973-1482
dc.identifier.issue2en_US
dc.identifier.pmid21768702en_US
dc.identifier.scopus2-s2.0-79960772713en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.82927
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18066
dc.identifier.volume7en_US
dc.identifier.wosWOS:000304671700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Radiation Proctitisen_US
dc.subjectDaflonen_US
dc.subjectFlavonoid Fractionsen_US
dc.subjectRadiotherapyen_US
dc.subjectDaflon 500mgen_US
dc.subjectDouble-Blinden_US
dc.subjectRadiotherapyen_US
dc.subjectIrradiationen_US
dc.subjectTrialen_US
dc.subjectSucralfateen_US
dc.subjectTherapyen_US
dc.subjectOxygenen_US
dc.subjectAciden_US
dc.subjectLifeen_US
dc.titleThe effect of a flavonoid fractions diosmin plus hesperidin on radiation-induced acute proctitis in a rat modelen_US
dc.typeArticleen_US

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