The role of neurotensin receptor 1 on fear memory in mice

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dc.contributor.authorAkbas, Sedef
dc.contributor.authorTopuz, Ruhan Deniz
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNeurotensin (NT) is commonly found in the central nervous system and the gastrointestinal tract and known to play role as a neurotransmitter/neuromodulator/neurohormone. We aimed to investigate the effect of the neurotensin receptor agonist PD149163 and the neurotensin receptor antagonist SR142948 on contextual and cued fear conditioning. In total 174 male Balb/c mice were divided into 29 groups. In the behavioral experiments, the NT receptor agonist PD149163 (0.25, 1, 4 mg/kg) or NT receptor antagonist SR142948 (0.1, 1, 3 mg/kg) were administered to subjects before conditioning on the first day (acquisition phase) or before the test performed 24 h after conditioning (retrieval). Rota-rod test, contextual and cued fear conditioning test were performed in all groups. It was observed that the neurotensin receptor agonist PD149163 had no effect on learning in the cued fear conditioning test, but enhanced retrieval dose-dependently. The neurotensin receptor antagonist SR142948 did not affect the learning and retrieval processes in cued fear conditioning. In the contextual fear conditioning test, neither the neurotensin receptor agonist PD149163 nor the neurotensin receptor antagonist SR142948 had any effect on the learning or retrieval of fear conditioning. Our results show that neurotensin receptor agonist PD149163 increases amygdala dependent cued fear conditioning responses dose-dependently.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP2018/44]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP2018/44). This work is presented at `25th National Pharmacology Congress' in Turkey 4-7 November 2019. We thank Cetin Hakan Karadag, Ahmet Ulugol and K. Duvan-Aydemir for their support.en_US
dc.identifier.doi10.29228/jrp.52
dc.identifier.endpage615en_US
dc.identifier.issn2630-6344
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85115742320en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage609en_US
dc.identifier.trdizinid489669en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.52
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/489669
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22705
dc.identifier.volume25en_US
dc.identifier.wosWOS:000701782800009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal Of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeurotensinen_US
dc.subjectHippocampusen_US
dc.subjectAmygdalaen_US
dc.subjectFear Conditioningen_US
dc.subjectFear Memoryen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectContextual Fearen_US
dc.subjectPd149163en_US
dc.subjectAntagonisten_US
dc.subjectModulationen_US
dc.subjectMechanismsen_US
dc.subjectPeptideen_US
dc.titleThe role of neurotensin receptor 1 on fear memory in miceen_US
dc.typeArticleen_US

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