Asymmetric dimethylarginine in experimental breast cancer; action of Vitamin C and E

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorErbas, Hakan
dc.contributor.authorTurksever, Aylin
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorCakir, Erol
dc.date.accessioned2024-06-12T10:55:10Z
dc.date.available2024-06-12T10:55:10Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To investigate the arginase-nitric oxide synthase paradox through asymmetric dimethylarginine, symmetric dimethylarginine and nitric oxide levels, and to see the effect of antioxidant vitamins on this mechanism of cancer action. Methods: The animal-based study was conducted at Trakya University, Turkey, in 2008, and comprised mice that were divided into five equal groups. Group 1 had healthy controls, while in the other four groups breast cancer was induced. Group 2 received saline solution, group 3 received 200 mg/kg/day vitamin C (tumour +vit C), group 4 received 300 mg/kg/day vitamin E (tumour +vitE) and group 5 received both 200 mg/kg/day vitamin C and 300 mg/kg/day vitamin E (tumour +vit C+vit E) for 15 days intra-peritoneally. Arginine, asymmetric dimethylarginine, symmetric dimethylarginine and nitric oxide levels were determined in each group. Results: The 50 mice in the study were divided into five groups of 10(20%) each. Plasma arginine levels were significantly decreased, asymmetric dimethylarginine and symmetric dimethylarginine levels were increased, while plasma nitric oxide level was significantly decreased in group 2. There was no statistically significant difference in treatment groups for all parameters (p>0.05 each). Conclusion: Understanding of the mechanism may help to develop new anti-cancer agents.en_US
dc.description.sponsorshipUniversity of Trakyaen_US
dc.description.sponsorshipWe are grateful to University of Trakya Research Project for financial assistance.en_US
dc.identifier.endpage833en_US
dc.identifier.issn0030-9982
dc.identifier.issue8en_US
dc.identifier.pmid26228325en_US
dc.identifier.scopus2-s2.0-84938118638en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage829en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19319
dc.identifier.volume65en_US
dc.identifier.wosWOS:000360444600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal Of The Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectArginineen_US
dc.subjectADMAen_US
dc.subjectSDMAen_US
dc.subjectNOen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.subjectNitric-Oxideen_US
dc.subjectSymmetric Dimethylarginineen_US
dc.subjectArginase Activityen_US
dc.subjectPolyaminesen_US
dc.subjectMetabolismen_US
dc.subjectArginineen_US
dc.titleAsymmetric dimethylarginine in experimental breast cancer; action of Vitamin C and Een_US
dc.typeArticleen_US

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