Evaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorder

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridvardar, mehmet erdal/0000-0002-5836-6174
dc.authoridTAYFUR, PINAR/0000-0002-2825-0760
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidvardar, mehmet erdal/ABI-5764-2020
dc.contributor.authorDurmus, Pelin Tas
dc.contributor.authorVardar, Mehmet Erdal
dc.contributor.authorKaya, Oktay
dc.contributor.authorTayfur, Pinar
dc.contributor.authorSut, Necdet
dc.contributor.authorVardar, Selma Arzu
dc.date.accessioned2024-06-12T10:59:21Z
dc.date.available2024-06-12T10:59:21Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Opioid use disorder (OpUD) is a biological and psychosocial disorder with limited treatment options. Addition of physical exercise to the pharmacological treatment has been proposed to be effective on reducing substance use and improving the quality of life. In this study we aimed to investigate the effects of a high-intensity interval training (HIIT) program on the serum levels of cortisol, insulin-like growth factor1 (IGF-1), interferon-gamma (IFN-gamma), interleukin 17 (IL-17) and the clinical progress of inpatients with OpUD. Method: Our study enrolled 22 male inpatients diagnosed with OpUD on the basis of the DSM-5 criteria. Two groups of 11 individuals were formed as the exercise (EG) and the control (CG) groups. The EG conducted 5 sessions of a HIIT. Participant data were collected with Sociodemographic Questionnaire, the Addiction Profile Index (API), and the Barratt Impulsiveness Scale (BIS-11). Also, the Hamilton Depression Rating Scale (HAM-D), the Hamilton Anxiety Rating Scale (HAM-A) and the Substance Craving Scale (SCS) were used before and after the treatment program in order to evaluate the clinical progress. Blood samples were collected on the 5th and the 21st days for estimation of the serum cortisol, IGF-1, IFN-gamma and the IL-17 levels. Results: Comparison of the pre- and the post-treatment performances of the two groups on the HAM-D, the HAM-A and the SCS indicated a significant drop in the respective scores of the EG. Also, a significant increase was observed in the post-treatment IGF-1 level of the EG as compared to the CG. No differences were observed between the cortisol, IFN-gamma and IL-17 levels of the EG and the CG. Conclusion: HIIT resulted in significant reduction in the symptoms of depression, anxiety and substance craving, and increased the serum IGF-1 levels. HIIT did not change serum cortisol, IFN-gamma and IL-17 levels. We believe this research will contribute to the literature on the treatment of opioid depencence by emphasising the effects of HIIT on patients treated for OpUD.en_US
dc.identifier.doi10.5080/u25070
dc.identifier.endpage158en_US
dc.identifier.issn1300-2163
dc.identifier.issue3en_US
dc.identifier.pmid32978950en_US
dc.identifier.scopus2-s2.0-85091807277en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage151en_US
dc.identifier.trdizinid415058en_US
dc.identifier.urihttps://doi.org/10.5080/u25070
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/415058
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20396
dc.identifier.volume31en_US
dc.identifier.wosWOS:000616943600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDependenceen_US
dc.subjectExerciseen_US
dc.subjectHeroinen_US
dc.subjectOpioiden_US
dc.subjectCytokineen_US
dc.subjectCortisolen_US
dc.subjectGrowth-Factor-Ien_US
dc.subjectMethamphetamine-Dependent Individualsen_US
dc.subjectSubstance Useen_US
dc.subjectNeurotrophic Factoren_US
dc.subjectIgf-Ien_US
dc.subjectExerciseen_US
dc.subjectDepressionen_US
dc.subjectHeroinen_US
dc.subjectAddictionen_US
dc.subjectResponsesen_US
dc.titleEvaluation of the Effects of High Intensity Interval Training on Cytokine Levels and Clinical Course in Treatment of Opioid Use Disorderen_US
dc.typeArticleen_US

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