A retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkey

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dc.authorscopusid55892412500
dc.authorscopusid55406602400
dc.authorscopusid17341367900
dc.authorscopusid55727791600
dc.authorscopusid7004756072
dc.authorscopusid6701564916
dc.authorscopusid6701818388
dc.contributor.authorTuglular S.
dc.contributor.authorYalcinkaya F.
dc.contributor.authorPaydas S.
dc.contributor.authorOner A.
dc.contributor.authorUtas C.
dc.contributor.authorBozfakioglu S.
dc.contributor.authorAtaman R.
dc.date.accessioned2024-06-12T10:25:21Z
dc.date.available2024-06-12T10:25:21Z
dc.date.issued2002
dc.description.abstractBackground. Secondary amyloidosis is the most frequent of the various types of systemic amyloidosis, the epidemiology of which is not yet fully known. The aim of our study was to evaluate retrospectively the collective data for the aetiological distribution, clinical findings and approaches to the management of secondary amyloidosis in Turkey. Methods. Data from a simple questionnaire addressing aetiology, and demographic and clinical characteristics of patients with biopsy-proven secondary amyloidosis was retrospectively analysed. Eleven nephrology clinics contributed data for this study. Results. The 11 contributing centres provided a total of 287 cases (102 female, 185 male). The aetiological distribution was as follows: familial Mediterranean fever (FMF) 64%, tuberculosis 10%, bronchiectasis and chronic obstructive lung disease 6%, rheumatoid arthritis 4%, spondylarthropathy 3%, chronic osteomyelitis 2%, miscellaneous 4%, unknown 7%. Oedema accompanied by proteinuria was present in 88% of the cases, hepatomegaly in 17%, and splenomegaly in 11%. The mean systolic and diastolic blood pressures were 115 ± 26 and 73 ± 15 mmHg respectively. The family history was positive in 16%; 73% of the cases were on colchicine treatment when the questionnaire was administered. Thirty-eight per cent of the cases had progressed to ESRD and were on renal replacement therapy. Conclusions. FMF is the leading cause of secondary amyloidosis in Turkey, followed by tuberculosis. Oedema accompanied by proteinuria is the most prominent presenting finding, and hypotension seems to be common among these patients.en_US
dc.identifier.doi10.1093/ndt/17.11.2003
dc.identifier.endpage2005en_US
dc.identifier.issn0931-0509
dc.identifier.issue11en_US
dc.identifier.pmid12401861en_US
dc.identifier.scopus2-s2.0-0036842108en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2003en_US
dc.identifier.urihttps://doi.org/10.1093/ndt/17.11.2003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16274
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAetiology; Amyloidosis; Clinical Findings; End-Stage Renal Disease; Family Historyen_US
dc.subjectColchicine; Adult; Amyloidosis; Article; Biopsy Technique; Blood Pressure Measurement; Bronchiectasis; Chronic Obstructive Lung Disease; Chronic Osteomyelitis; Clinical Feature; Controlled Study; Data Analysis; Diastolic Blood Pressure; Disease Course; Edema; Familial Mediterranean Fever; Family History; Female; Hepatomegaly; Human; Hypotension; Kidney Failure; Kidney Transplantation; Major Clinical Study; Male; Nephrology; Outpatient Department; Priority Journal; Proteinuria; Questionnaire; Retrospective Study; Rheumatoid Arthritis; Splenomegaly; Spondyloarthropathy; Systolic Blood Pressure; Tuberculosis; Turkey (Republic); Adolescent; Amyloidosis; Child; Chronic Kidney Failure; Edema; Familial Mediterranean Fever; Middle Aged; Proteinuria; Renal Replacement Therapy; Tuberculosis; Adolescent; Adult; Amyloidosis; Child; Colchicine; Edema; Familial Mediterranean Fever; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Proteinuria; Questionnaires; Renal Replacement Therapy; Retrospective Studies; Tuberculosisen_US
dc.titleA retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkeyen_US
dc.typeArticleen_US

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