The effects of glycyrrhizin on experimental acute pancreatitis in rats

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dc.authoridinal, volkan/0000-0003-2649-104X
dc.authoridYILDIRIM, Ali Osman/0000-0003-3317-5395
dc.authorwosidOztas, Emin/B-5730-2016
dc.authorwosidinal, volkan/A-6069-2018
dc.contributor.authorYildirim, A. O.
dc.contributor.authorInce, M.
dc.contributor.authorEyi, Y. E.
dc.contributor.authorTuncer, S. K.
dc.contributor.authorKaldirim, U.
dc.contributor.authorEroglu, M.
dc.contributor.authorOztas, E.
dc.date.accessioned2024-06-12T11:02:47Z
dc.date.available2024-06-12T11:02:47Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractINTRODUCTION: Although physiopathology of acute pancreatitis (AP) is not fully understood, the roles of reactive oxygen species (ROS) and changes of cytokines have been determined. AIM: To investigate anti-inflammatory and anti-oxidant effects of glycyrrhizin (GL) on taurocholate-induced AP in rats. MATERIALS AND METHODS: Thirty six rats were randomly divided into three groups as sham, AP and AP+GL (n=12 per group). AP was induced by 1 ml/kg body weight using 5% taurocholate injection into the biliopancreatic duct in groups II and III after clamping the hepatic duct. In groups III, GL (20 mg/kg) was given by oral gavage twice daily for 4 days. Group I and II did not receive any treatment. After the rats were killed; blood samples were taken to measure amylase, lipase, calcium, albumin, urea, glucose, AST and LDH assays before killing. Pancreatic tissue samples were also taken for biochemical analyses and histopathology. RESULTS: Amylase, lipase, AST and urea levels were significantly lower in the AP+GL group than in the AP group. Cytokines including IL-6, TNF-alpha and MPO levels were significantly lower in the AP+GL group than in the AP group. Even so there is no statistically difference between in the AP+GL group and the AP group in terms of pancreatic tissue IL-1 beta, IL-6 and TNF-alpha levels. DISCUSSION: GL treatment significantly decreased pancreatic tissue MPO activities and MDA levels in the AP+GL group compared with the other groups (p = 0.001 and p = 0.05, respectively). Acinar cell necrosis, hemorrhage, and edema determined that were significantly lower in the AP+GL group than in the AP group (p < 0.001). CONCLUSIONS: GL treatment for acute necrotizing pancreatitis in rats suppressed the levels of pro-inflammatory cytokines, and caused a clear recovery of histological changes.en_US
dc.identifier.endpage2987en_US
dc.identifier.issn1128-3602
dc.identifier.issue22en_US
dc.identifier.pmid24302175en_US
dc.identifier.scopus2-s2.0-84891814808en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2981en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21392
dc.identifier.volume17en_US
dc.identifier.wosWOS:000328085300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlycyrrhizinen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectPro-Inflammatory Cytokinesen_US
dc.subjectGlycyrrhetinic-Aciden_US
dc.subjectPathogenesisen_US
dc.subjectLicoriceen_US
dc.subjectModelen_US
dc.subjectMelatoninen_US
dc.subjectSeverityen_US
dc.subjectIschemiaen_US
dc.subjectEtiologyen_US
dc.subjectInjuryen_US
dc.titleThe effects of glycyrrhizin on experimental acute pancreatitis in ratsen_US
dc.typeArticleen_US

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