Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorKaradag, Hakan C.
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T10:51:18Z
dc.date.available2024-06-12T10:51:18Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description7th Congress of the European Federation of IASP Chapters -- SEP 21-24, 2011 -- Hamburg, GERMANYen_US
dc.description.abstractCombinations of analgesics from different classes are commonly used in the management of chronic pain. The goal is to enhance pain relief together with the reduction of side effects. The present study was undertaken to examine the anti-allodynic synergy resulting from the combination of WIN 55,212-2, a cannabinoid CBI receptor agonist, and JTC-801, a nociceptin/orphanin FQ receptor antagonist, on neuropathic pain. Mice were tested for behavioral effects before and 2-4 weeks after the surgery, in which a partial tight ligation of the sciatic nerve was made. Nerve injury-induced mechanical allodynia was assessed with Dynamic Plantar Aesthesiometer, and a hot/cold plate was used to assess cold allodynia. Both WIN 55,212-2 and JTC-801 produced dose-dependent mechanical and cold anti-allodynic effects. As shown by isobolographic analysis, WIN 55,212-2/JTC-801 combinations interacted synergistically at all three ratios studied in the mechanical allodynia assay. In conclusion, co-administration of a cannabinoid with a nociceptin/orphanin FQ receptor antagonist resulted in a synergistic interaction, which may have utility in the pharmacological treatment of neuropathic pain. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pbb.2011.05.029
dc.identifier.endpage544en_US
dc.identifier.issn0091-3057
dc.identifier.issue4en_US
dc.identifier.pmid21664922en_US
dc.identifier.scopus2-s2.0-79959248139en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage540en_US
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2011.05.029
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18300
dc.identifier.volume99en_US
dc.identifier.wosWOS:000294880100003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPharmacology Biochemistry And Behavioren_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllodyniaen_US
dc.subjectCannabinoidsen_US
dc.subjectNociceptinen_US
dc.subjectSynergismen_US
dc.subjectNeuropathic Painen_US
dc.subjectNerve Injuryen_US
dc.subjectReceptor Antagonisten_US
dc.subjectTactile Allodyniaen_US
dc.subjectRat Modelen_US
dc.subjectPainen_US
dc.subjectMorphineen_US
dc.subjectToleranceen_US
dc.subjectJtc-801en_US
dc.subjectPotentiationen_US
dc.subjectCombinationen_US
dc.titleSynergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic miceen_US
dc.typeConference Objecten_US

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