Synthesis, characterization of some transition-metal complexes of a new heptadentate N5S2 Schiff-base ligand and the effects of these metal complexes on U2OS cells cytotoxicity and DNA cleavage activity
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Metal complexes of a heptadentate N5S2 donor Schiff-base ligand were synthesized by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2 '-bipyridine-6,6'-dicarboxaldehyde in the presence of Zn(II), Cd(II), Hg(II) and Pb(II) perchlorate salts. The complexes were characterized by IR, 1H NMR, MS-FAB+, and elemental analyses. The mitochondrial activity of U2OS cells after exposure to these complexes was determined by colorimetric assay, which detects the conversion of 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) to formazon. DNA-binding activity of all complexes was also investigated using plasmid DNA pUC18 purified from E. coli.
Açıklama
Anahtar Kelimeler
Mitocondrial Activity, MTT, Schiff Base, Template Synthesis, Crystal-Structures, Thiosemicarbazone, Coordination, Ions
Kaynak
Phosphorus Sulfur And Silicon And The Related Elements
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
183
Sayı
9
