Endothelial cell density of the cornea during rigid gas permeable contact lens wear

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dc.authorscopusid6602300890
dc.authorscopusid6507877529
dc.contributor.authorEsgin H.
dc.contributor.authorErda N.
dc.date.accessioned2024-06-12T10:28:10Z
dc.date.available2024-06-12T10:28:10Z
dc.date.issued2000
dc.description.abstractPurpose: To determine the influence of a daily wear rigid gas permeable (RGP) high DK lens (CIBA Vision Persecon92E, Dk=92 x 10-11) on corneal endothelial cell density (ECD). Methods: A prospective longitudinal, follow- up study was conducted. Variations in corneal ECD during the first year were reported. For this purpose, the endothelium of 97 eyes of 57 unadapted subjects were compared by specular microscopy before and after 1 week (n= 74), 1 month (n=67), 3 months (n=51), and 1 year (n=23) of wearing contact lenses. Results: There was a significant decrease in cell density vs age (r=- 0.28), P=0.005). ECD significantly increased 1 week (3.6%) (P=-0.001), 1 month (3.6%) (P=-0.003), and 3 months (4.5%) (P=-0.003) after contact lens wear. One year after the lens fitting, a similar but not significant increase was found. While ECD increase was insignificant with initially high ECD subjects (>2700 cells/mm2), subjects with low ECG initially (<2700 cells/ mm2) showed a significant increase in ECD in all time intervals. Conclusions: In the 1 week RGP contact lens wearing period, the endotheliums with low ECD probably adapted to a new oxygen environment by cell migration or mitotic activity. The increased ECD was perhaps related to the daily wear schedule in which the oxygen partial pressure was sufficient.en_US
dc.identifier.endpage150en_US
dc.identifier.issn0733-8902
dc.identifier.issue3en_US
dc.identifier.pmid10946986en_US
dc.identifier.scopus2-s2.0-0033913311en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17114
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCLAO Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdolescent; Adult; Article; Cell Density; Cell Migration; Cornea Endothelium; Female; Follow Up; Gas Permeability; Hard Contact Lens; Human; Major Clinical Study; Male; Mitosis; Oxygen Tension; Refraction Error; School Child; Specular Microscopy; Adolescent; Adult; Aging; Cell Count; Cell Movement; Child; Contact Lenses, Extended-Wear; Contrast Media; Endothelium, Corneal; Female; Fluorescein; Follow-Up Studies; Humans; Male; Middle Aged; Ophthalmic Solutions; Oxygen; Permeability; Prospective Studiesen_US
dc.titleEndothelial cell density of the cornea during rigid gas permeable contact lens wearen_US
dc.typeArticleen_US

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