Depression of glucose levels and partial restoration of pancreatic ?-cell damage by melatonin in streptozotocin-induced diabetic rats

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dc.authoridUYSAL, HAMDI/0000-0002-2289-1815
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosidUYSAL, HAMDI/AAF-9708-2020
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUysal, Hamdi
dc.contributor.authorKaraca, Turan
dc.contributor.authorSagmanligil, Hulya Ozdemir
dc.date.accessioned2024-06-12T11:12:02Z
dc.date.available2024-06-12T11:12:02Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDiabetes mellitus is a common but serious metabolic disorder associated with many functional and structural complications. Glucose metabolism is disturbed due to an absolute or relative insulin deficiency. The experiment was carried out to determine the effect of melatonin on blood glucose and insulin concentrations, and histopathology of pancreatic beta-cells in streptozotocin (STZ)-induced diabetic rats. The rats were randomly allocated into one of the four experimental groups: group A (control), group B (diabetic untreated), group C (diabetic treated with melatonin for 6 weeks) and group D (diabetic treated with melatonin for 8 weeks); each group contained ten animals. Diabetes was induced in B, C and D groups by a single intraperitoneal (i.p.) injection of STZ (50 mg/kg, freshly dissolved in 5 mmol/l citrate buffer, pH 4.5). The rats in melatonin-treated groups were subjected to the daily i.p injection of 10 mg kg(-1) of melatonin for 6 or 8 weeks starting the day after STZ injection. Control and diabetic untreated rats were injected with the same volume of isotonic NaCl as the melatonin treated groups. Almost all insulin-positive beta-cells were degranulated, degenerated or necrotic in the STZ-treated rats leading to decrease in insulin secretion and an increase in blood glucose concentration. Melatonin treatment caused a sharp decrease in the elevated serum glucose, a slight increase in the lowered serum insulin concentrations and small partial regeneration/proliferation of beta-cells of islets. It is concluded that the hypoglycemic action of melatonin could be partly due to small amelioration in the beta-cells of pancreatic islets causing a slight increase in insulin secretion, it is mostly due to the extrapancreatic actions of the melatonin.en_US
dc.identifier.doi10.1007/s00204-005-0055-z
dc.identifier.endpage369en_US
dc.identifier.issn0340-5761
dc.identifier.issn1432-0738
dc.identifier.issue6en_US
dc.identifier.pmid16341692en_US
dc.identifier.scopus2-s2.0-33646587038en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://doi.org/10.1007/s00204-005-0055-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23005
dc.identifier.volume80en_US
dc.identifier.wosWOS:000237501300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPancreatic Beta-Cellsen_US
dc.subjectGlucoseen_US
dc.subjectInsulinen_US
dc.subjectRegenerationen_US
dc.subjectRatsen_US
dc.subjectPoly(Adp-Ribose) Polymerase Geneen_US
dc.subjectDna Strand Breaksen_US
dc.subjectOxidative Stressen_US
dc.subjectBlood-Glucoseen_US
dc.subjectProtectsen_US
dc.subjectIsletsen_US
dc.subjectMiceen_US
dc.subjectHyperglycemiaen_US
dc.subjectPinealectomyen_US
dc.subjectSynthetaseen_US
dc.titleDepression of glucose levels and partial restoration of pancreatic ?-cell damage by melatonin in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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