The prevalence of non-vascular pulmonary manifestations in Takayasu's Arteritis patients: A Retrospective multi-centred Turkish cohort study

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dc.authoridAksu, Kenan/0000-0001-8889-2688
dc.authoridOzdemir Isik, Ozlem/0000-0002-2985-3723
dc.authoridKanıtez, Nilüfer Alpay/0000-0003-1185-5816
dc.authoridYazıcı, Ayten/0000-0003-2167-4509;
dc.authorwosidAksu, Kenan/HLH-8218-2023
dc.authorwosidKaymaz Tahra, Sema/GPP-1272-2022
dc.authorwosidOzdemir Isik, Ozlem/JDV-5142-2023
dc.authorwosidKanıtez, Nilüfer Alpay/W-7332-2019
dc.authorwosidYazıcı, Ayten/AAT-3636-2020
dc.authorwosidIşık, Özlem/JBI-6627-2023
dc.authorwosidOnen, Fatos/AAA-8970-2021
dc.contributor.authorYazici, A.
dc.contributor.authorKaymaz-Tahra, S.
dc.contributor.authorIsik, O. Ozdemir
dc.contributor.authorKara, M.
dc.contributor.authorAlpay-Kanitez, N.
dc.contributor.authorGercik, O.
dc.contributor.authorOmma, A.
dc.date.accessioned2024-06-12T11:19:12Z
dc.date.available2024-06-12T11:19:12Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives Takayasu's arteritis (TAK) is a rare vasculitis characterized by inflammation of intermediate- to large-size arteries. Although pulmonary artery involvement (PAI) is an expected finding in some TAK patients, data on non-vascular pulmonary involvement (NVPI) are limited. We aimed to investigate the frequency of NVPI, including parenchymal infiltration, nodules/cavities, pleural effusion, and haemorrhage, in TAK. Method We assembled a retrospective cohort of TAK patients from nine tertiary centres in Turkey. The demographics and clinical characteristics of patients were extracted from medical records and the imaging findings were evaluated for pulmonary manifestations. Results As of January 2021, 319 TAK patients (female/male 276/43; mean age 42.4 +/- 13.5 years) were recruited. Eighty-two patients had cough and/or dyspnoea and four had haemoptysis as pulmonary symptoms. On computed tomography assessment, the overall frequency of NVPI was 7.2%; parenchymal infiltrations were present in 10 (3.1%), pleural effusion in eight (2.5%), nodules/cavities in six (1.9%), and pulmonary haemorrhage in four patients (1.3%). In the whole cohort, 10.3% of patients had pulmonary artery hypertension (PAH) and 5.6% had PAI. Among patients with PAH or PAI, the overall frequency of NVPI was significantly higher than in the rest of the group. Conclusions In this TAK cohort from Turkey, we observed NVPI in 7.2% of patients, with parenchymal infiltrations being the most common, followed by pleural effusion. Notably, NVPI was more frequent in patients with PAH or PAI. Although not as common as PAI, NVPI should be kept in mind, especially in TAK patients with PAH or PAI.en_US
dc.identifier.doi10.1080/03009742.2021.1972535
dc.identifier.endpage308en_US
dc.identifier.issn0300-9742
dc.identifier.issn1502-7732
dc.identifier.issue4en_US
dc.identifier.pmid34643164en_US
dc.identifier.scopus2-s2.0-85117162006en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.1080/03009742.2021.1972535
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25111
dc.identifier.volume51en_US
dc.identifier.wosWOS:000707092500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInvolvementen_US
dc.titleThe prevalence of non-vascular pulmonary manifestations in Takayasu's Arteritis patients: A Retrospective multi-centred Turkish cohort studyen_US
dc.typeArticleen_US

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