Characteristics and analysis of risk factors for mortality in infective endocarditis

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dc.authorscopusid24073322700
dc.authorscopusid57197053881
dc.authorscopusid6603131490
dc.authorscopusid8726721500
dc.authorscopusid7004231756
dc.authorscopusid6603910640
dc.authorscopusid14423913000
dc.contributor.authorLeblebicioglu H.
dc.contributor.authorYilmaz H.
dc.contributor.authorTasova Y.
dc.contributor.authorAlp E.
dc.contributor.authorSaba R.
dc.contributor.authorCaylan R.
dc.contributor.authorBakir M.
dc.date.accessioned2024-06-12T10:24:57Z
dc.date.available2024-06-12T10:24:57Z
dc.date.issued2006
dc.description.abstractObjective: The aim of our study was to establish the etiology of and risk factors for infective endocarditis (IE) and determine the prognostic factors for adverse outcome during hospital admission in a Turkish population. Material and Methods: Between January 2002 and January 2004, the clinical and laboratory features of 112 consecutive adult patients (>18 years) with diagnosis of IE who were referred to the infectious diseases clinics/departments of 17 teaching hospitals in Turkey were evaluated. Cases of IE were defined according to the modified Duke Criteria. Mortality was defined as death occurring within 30 days or during hospital stay period. Univariate and multivariate analyses were performed to predict the factors related to fatal outcome. Results: A total of 112 consecutive patients presented with 101 definite and 11 probable IE episodes were defined according to the modified Duke Criteria. The mean age was 45.2±19.9. Fifty percent of the patients were male. Ninety (60.4%) of the 112 patients had risk factors for IE and 48 (42.9%) of them had ?2 risk factors. On the other hand, 49.1% of patients had cardiac risk factors. Blood cultures were positive in 94 (83.9%) cases. Staphylococci were the most common agents (50.0%), followed by streptococci (28.7%) and enterococi (16.0%). Native cardiac valves were detected in 93 (83%) of the episodes of suspected IE. Valvular involvement was present in 103 (92%) patients; the mitral valve, alone or in combination with other valves, was affected in 70 (62.5%) of the patients. Echocardiography detected vegetations in 105 patients (93.8%). The mortality rate was 28.6%. Three factors were independently associated with mortality: haemodialysis OR: 14.5 (95% CI: 1.5-138.2), mobile vegetation OR: 4.8 (95% CI: 1.5-15.4) and mental alteration OR: 4.1 (95% CI: 1.1-15.6). Conclusion: Mortality is still high in IE. Our data indicate that patients with altered mental status, mobile vegetation, or on haemodialysis had poorer prognosis. © Springer 2006.en_US
dc.identifier.doi10.1007/s10654-005-4724-2
dc.identifier.endpage31en_US
dc.identifier.issn0393-2990
dc.identifier.issue1en_US
dc.identifier.pmid16450203en_US
dc.identifier.scopus2-s2.0-31944433220en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1007/s10654-005-4724-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16114
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Epidemiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocarditis; Haemodialysis; Mental Alteration; Mortality; Prognosis; Vegetationen_US
dc.subjectAdult; Analytic Method; Article; Bacterial Endocarditis; Cardiovascular Risk; Clinical Feature; Controlled Study; Echocardiography; Enterococcus; Evaluation; Female; Heart Valve; Hemodialysis; Hospital Admission; Hospitalization; Human; Laboratory Test; Major Clinical Study; Male; Mortality; Multivariate Analysis; Outcomes Research; Patient Referral; Prognosis; Risk Assessment; Risk Factor; Staphylococcus; Teaching Hospital; Univariate Analysis; Vegetation; Chi-Square Distribution; Demography; Echocardiography; Endocarditis, Bacterial; Female; Humans; Male; Middle Aged; Persistent Vegetative State; Prognosis; Renal Dialysis; Risk Factors; Turkeyen_US
dc.titleCharacteristics and analysis of risk factors for mortality in infective endocarditisen_US
dc.typeArticleen_US

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