Correction of differential renal function for asymmetric renal area ratio in unilateral hydronephrosis

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dc.authoridAktas, Gul Ege/0000-0003-4880-2275
dc.authorwosidAktas, Gul Ege/R-1776-2019
dc.contributor.authorAktas, Gul Ege
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T11:03:27Z
dc.date.available2024-06-12T11:03:27Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractChildren with unilateral hydronephrosis are followed up with anteroposterior pelvic diameter (APD), hydronephrosis grade, mercaptoacetyltriglycine (MAG-3) drainage pattern and differential renal function (DRF). Indeterminate drainage preserved DRF in higher grades of hydronephrosis, in some situations, complicating the decision-making process. Due to an asymmetric renal area ratio, falsely negative DRF estimations can result in missed optimal surgery times. This study was designed to assess whether correcting the DRF estimation according to kidney area could reflect the clinical situation of a hydronephrotic kidney better than a classical DRF calculation, concurrently with the hydronephrosis grade, APD and MAG-3 drainage pattern. We reviewed the MAG-3, dimercaptosuccinic acid (DMSA) scans and ultrasonography (US) of 23 children (6 girls, 17 boys, mean age: 29 +/- A 50 months) with unilateral hydronephrosis. MAG-3 and DMSA scans were performed within 3 months (mean 25.4 +/- A 30.7 days). The closest US findings (mean 41.5 +/- A 28.2 days) were used. DMSA DRF estimations were obtained using the geometric mean method. Secondary calculations were performed to correct the counts (the total counts divided by the number of pixels in ROI) according to kidney area. The renogram patterns of patients were evaluated and separated into subgroups. The visual assessment of DMSA scans was noted and the hydronephrotic kidney was classified in comparison to the normal contralateral kidney's uptake. The correlations of the DRF values of classical and area-corrected methods with MAG-3 renogram patterns, the visual classification of DMSA scan, the hydronephrosis grade and the APD were assessed. DRF estimations of two methods were statistically different (p: 0.001). The categories of 12 hydronephrotic kidneys were changed. There were no correlations between classical DRF estimations and the hydronephrosis grade, APD, visual classification of the DMSA scan and uptake evaluation. The DRF distributions according to MAG-3 drainage patterns were not different. Area-corrected DRF estimations correlated with all: with an increasing hydronephrosis grade and APD, DRF estimations decreased and MAG-3 drainage patterns worsened. A decrease in DRF (< 45 %) was determined when APD was a parts per thousand yen10 mm. When APD was a parts per thousand yen26 mm, a reduction of DRF below 40 % was determined. Our results suggest that correcting DRF estimation for asymmetric renal area ratio in unilateral hydronephrosis can be more robust than the classical method, especially for higher grades of hydronephrotic kidneys, under equivocal circumstances.en_US
dc.identifier.doi10.1007/s12149-015-1009-z
dc.identifier.endpage824en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue9en_US
dc.identifier.pmid26228384en_US
dc.identifier.startpage816en_US
dc.identifier.urihttps://doi.org/10.1007/s12149-015-1009-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21670
dc.identifier.volume29en_US
dc.identifier.wosWOS:000363882000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydronephrosisen_US
dc.subjectDRFen_US
dc.subjectDMSAen_US
dc.subjectMAG-3en_US
dc.subjectSupranormal Functionen_US
dc.subjectUPJen_US
dc.subjectPelvic Diameteren_US
dc.subjectChildrenen_US
dc.subjectInfantsen_US
dc.subjectScanen_US
dc.subjectFacten_US
dc.titleCorrection of differential renal function for asymmetric renal area ratio in unilateral hydronephrosisen_US
dc.typeArticleen_US

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