THE EFFECT OF CEPAE EXTRACTUM-HEPARIN-ALLANTOIN IN THE PREVENTION OF PLEURAL ADHESIONS FOLLOWING THORACOTOMY IN RATS
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Carbone Editore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aims: The aim of this study was to assess the effects of cepae extractum-heparin on the prevention of pleural adhesions following thoracotomy in rats. Methods: 20 female Sprague-Dawley rats were used in this study. The rats were randomized into three groups. group I underwent only a thoracotomy. Animals in group 2 underwent thoracotomy with pleural abrasion, and animals in group 3 underwent thoracotomy with pleural abrasion and were treated with intrapleural application of cepae extractum-heparin-allantoin. The animals were sacrificed on the twenty-first day, and the adhesions were evaluated both microscopically and macroscopically. Results: The mean adhesion severity scores for groups 1, 2, and 3 were 1.25 +/- 0.50, 2.6 2 +/- 1.41 and 1.25 +/- 0.46, respectively. While there were no significant differences in the length of adhesions between group 1 and 2 (p>0.05), the difference was significant between groups I and 3, and also between 2 and 3 (p<0.05 for both). Comparison of the groups with respect to the adhesion severity score showed that there were no statistically significant differences between the groups (p>0.05). The difference between the groups with respect to thicknesses of the parietal and visceral pleurae showed no significant difference (p>0.05). Conclusion: The results showed that the use of cepae extractum-heparin-allantoin following thoracotomy decreased the pleural adhesions, however this decrease was not statistically significant.
Açıklama
Anahtar Kelimeler
Cepae Extractum-Heparin-Allantoin, Adhesion, Pleura, Rat, Reduction
Kaynak
Acta Medica Mediterranea
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
30
Sayı
3
