Assessment of the relationship between asymmetric dimethylarginine and severity of erectile dysfunction and coronary artery disease

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidBarutcu, Ahmet/HKE-7359-2023
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorAktoz, Meryem
dc.contributor.authorTatli, Ersan
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorTuran, Fatma N.
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorAtakan, Irfan H.
dc.date.accessioned2024-06-12T10:52:44Z
dc.date.available2024-06-12T10:52:44Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe plasma concentration of asymmetrical dimethylarginine (ADMA), an inhibitor of nitric oxide synthase, has been linked to endothelial dysfunction. We investigated the relation between plasma ADMA concentration and severity of erectile dysfunction (ED) and coronary artery disease (CAD). We measured plasma levels of ADMA in 92 male patients. Patients were divided into three groups: group 1 (n = 41), patients with ED and without CAD; group 2 (n = 29), patients with stable CAD; group 3 (n = 22), control group (patients without CAD or ED). Erectile function was evaluated by the erectile function domain of the international index of erectile function (IIEF-EFD) a validated 15-item self-administered questionnaire. Erectile function is specifically addressed by six questions that form the so-called erectile function domain of the questionnaire. Each question is scored 0-5. ED is defined as any value < 26. Patients with CAD who have stable angina pectoris were selected after coronary angiography. ADMA was analyzed by ELISA method. Group 1 had significantly higher concentrations of plasma ADMA than groups 2 and 3 (respectively, 0.75 +/- A 0.40 vs. 0.50 +/- A 0.30, P = 0.013; 0.75 +/- A 0.40 vs. 0.50 +/- A 0.25, P = 0.021). There was negative correlation between ADMA and IIEF-EFD score in all groups (n = 92) (r = -0.322, P = 0.002). In a multiple logistic regression analysis adjusting for age, hyperlipidemia, ADMA remained independent predictor for severe ED. Odds ratio for plasma ADMA was 14.151 (1.101-181.940; P = 0.042). First of all, this study provides that ADMA concentrations are significantly higher in patients who have ED when compared to patients with CAD and controls. Second, there was a negative correlation between ADMA and severity of ED. Elevating levels of circulating ADMA is an independent risk factor for severe of ED, and ADMA may be a link between CAD and ED.en_US
dc.identifier.doi10.1007/s11255-009-9696-9
dc.identifier.endpage879en_US
dc.identifier.issn0301-1623
dc.identifier.issue4en_US
dc.identifier.pmid20091222en_US
dc.identifier.scopus2-s2.0-78751642449en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage873en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-009-9696-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18806
dc.identifier.volume42en_US
dc.identifier.wosWOS:000284852000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetrical Dimethylarginineen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectCardiovascular Risk-Factorsen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectSynthase Inhibitorsen_US
dc.subjectVascular Functionen_US
dc.subjectNitric-Oxideen_US
dc.subjectL-Arginineen_US
dc.subjectAtherosclerosisen_US
dc.subjectAssociationen_US
dc.subjectAdmaen_US
dc.subjectMenen_US
dc.titleAssessment of the relationship between asymmetric dimethylarginine and severity of erectile dysfunction and coronary artery diseaseen_US
dc.typeArticleen_US

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