The neuroprotective effect of Sulindac after ischemia-reperfusion injury in rats1

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dc.authoridAras, Adem bozkurt/0000-0002-0140-5224
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authorwosidAras, Adem bozkurt/HTN-3829-2023
dc.authorwosidGuven, Mustafa/C-7731-2013
dc.authorwosidAkman, Tarık/JWA-2034-2024
dc.authorwosidguven, mustafa/I-6840-2013
dc.contributor.authorCosar, Murat
dc.contributor.authorKaner, Tuncay
dc.contributor.authorSahin, Onder
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPURPOSE:To investigate the neuroprotective effects of Sulindac on the hippocampal complex after global cerebral ischemia/reperfusion (I/R) injury in rats. METHODS: Thirty one Sprague- Dawley rats were used, distributed into group I (sham) n: 7 were used as control. For group II (n: 8), III (n: 8) and IV (n: 8) rats, cerebral ischemia was performed via the occlusion of bilateral internal carotid artery for 45 minutes and continued with reperfusion process. 0.3 mL/kg/h 0.9 % sodium chloride was infused intraperitoneally to the Group II rats before ischemia, 5 mu g/kg/h/0.3 ml sulindac was infused intraperitoneally to the Group III rats before ischemia and 5 mu g/kg/h/0.3 ml sulindac was infused intraperitoneally to the Group IV rats after ischemia and before reperfusion process. The levels of MDA, GSH and MPO activity were measured in the left hippocampus tissue. The hippocampal tissue of all group members were taken for histopathological study. RESULTS: The MDA and MPO levels increased from group I (control) to group II (I/R) (P < 0.05) and decreased from group II (I/R) to group III (presulindac + I/R) and IV (postsulindac + I/R) (P < 0.05). Beside these, the GSH levels decreased from group I (control) to group II (I/R) (P < 0.05) and increased from group II (I/R) to group III (presulindac + I/R) and IV (postsulindac + I/R) (P < 0.05). The number of apoptotic neurons increased from group I (control) to group II (I/R) (P < 0.05) and decreased from group II (I/R) to group III (presulindac + I/R) and IV (postsulindac + I/R) (P < 0.05). CONCLUSION: The Sulindac may have neuroprotective effects on ischemic neural tissue to prevent the reperfusion injury after ischemia.en_US
dc.identifier.doi10.1590/S0102-86502014000400008
dc.identifier.endpage273en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4en_US
dc.identifier.pmid24760028en_US
dc.identifier.scopus2-s2.0-84898840434en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage268en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-86502014000400008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23600
dc.identifier.volume29en_US
dc.identifier.wosWOS:000334997000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectReperfusion Injuryen_US
dc.subjectNeuroprotective Agentsen_US
dc.subjectSulindacen_US
dc.subjectRatsen_US
dc.subjectSprague-Dawleyen_US
dc.subjectFocal Cerebral-Ischemiaen_US
dc.subjectOxidative Stressen_US
dc.subjectReactive Oxygenen_US
dc.subjectDamageen_US
dc.subjectRadicalsen_US
dc.subjectBrainen_US
dc.subjectApoptosisen_US
dc.subjectNeuronsen_US
dc.titleThe neuroprotective effect of Sulindac after ischemia-reperfusion injury in rats1en_US
dc.typeArticleen_US

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