Asymmetrical dimethylarginine and severity of erectile dysfunction and their impact on cardiovascular events in patients with acute coronary syndrome

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dc.authoridAltun, Armagan/0000-0002-3233-8263;
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.authorwosidBarutcu, Ahmet/HKE-7359-2023
dc.contributor.authorAktoz, Meryem
dc.contributor.authorAktoz, Tevfik
dc.contributor.authorTatli, Ersan
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorTuran, Fatma Nesrin
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorAtakan, Irfan Hueseyin
dc.date.accessioned2024-06-12T10:50:32Z
dc.date.available2024-06-12T10:50:32Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Coronary artery disease (CAD) and vascular erectile dysfunction (ED) are related to endothelial dysfunction. Elevated asymmetrical dimethylarginine (ADMA) levels and ED are common in patients with increased cardiovascular risk. Our aim was to investigate whether ADMA has a predictive role for major adverse cardiovascular events (MACE) in acute coronary syndrome (ACS). The secondary aim of this study was to investigate whether severity of ED predicts MACE in these patients. Material and methods: Follow-up data were available for severity of ED in 71 patients with ACS. Plasma ADMA levels were determined by ELISA in 57 patients. Erectile dysfunction was assessed by the International Index of Erectile Function-6 (IIEF-6) score. Major adverse cardiovascular events (reinfarction, all-cause hospitalisation, stroke and all-cause death) was evaluated after a median of 10 months. Results: Severe ED had no significantly increased hazard ratio for cardiovascular events compared with mild, mild to moderate, and moderate ED (0.259 [95% CI 0.041-1.6], p = 0.147; 0.605 [95% CI 0.095-3.8], p = 0.594; 0.980 [95% CI 0.233-4.1], p = 0.978; and 0.473 [95% CI 0.052-1.3], p = 0.508). The patients who had ADMA levels 0.32 mu mol/l had no significantly increased hazard ratio for cardiovascular events compared with patients who had ADMA levels < 0.32 mu mol/l (2.018 [95% CI 0.615-6.6], p = 0.247). Conclusions: Severity of ED and ADMA did not increase the risk of cardiovascular events in follow-up patients with ACS in our study. Larger prospective studies are necessary to evaluate whether ADMA predicts cardiovascular events in patients with ACS.en_US
dc.identifier.doi10.5114/aoms.2010.13888
dc.identifier.endpage175en_US
dc.identifier.issn1734-1922
dc.identifier.issue2en_US
dc.identifier.pmid22371741en_US
dc.identifier.scopus2-s2.0-77951945690en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2010.13888
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18039
dc.identifier.volume6en_US
dc.identifier.wosWOS:000279340800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectMajor Adverse Cardiovascular Eventsen_US
dc.subjectAcute Myocardial-Infarctionen_US
dc.subjectNitric-Oxide Synthesisen_US
dc.subjectArtery-Diseaseen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectRisk-Factoren_US
dc.subjectPlasma-Levelsen_US
dc.subjectStrokeen_US
dc.subjectAdmaen_US
dc.subjectHypercholesterolemiaen_US
dc.subjectInhibitoren_US
dc.titleAsymmetrical dimethylarginine and severity of erectile dysfunction and their impact on cardiovascular events in patients with acute coronary syndromeen_US
dc.typeArticleen_US

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