Synthesis and characterization of biodegradable polyurethanes made from cholic acid and L-lysine diisocyanate ethyl ester

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dc.authoridAltinkok, Cagatay/0000-0002-0262-4154
dc.authoridKARATAVUK, Ali Osman/0000-0001-6616-4065
dc.authoridKARABULUT, H R Ferhat/0000-0002-9501-6296
dc.authoridAcik, Gokhan/0000-0002-9427-0508
dc.authorwosidAltinkok, Cagatay/ABA-9208-2020
dc.authorwosidKARATAVUK, Ali Osman/AAE-8175-2019
dc.authorwosidKARABULUT, H R Ferhat/AAA-1402-2021
dc.authorwosidAcik, Gokhan/M-5880-2019
dc.contributor.authorAcik, Gokhan
dc.contributor.authorKarabulut, Huseyin Riza Ferhat
dc.contributor.authorAltinkok, Cagatay
dc.contributor.authorKaratavuk, Ali Osman
dc.date.accessioned2024-06-12T10:54:37Z
dc.date.available2024-06-12T10:54:37Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this work, a series of biodegradable polyurethanes (PURs) based on cholic acid (CA) and L-lysine diisocyanate ethyl ester (L-LDI) that are renewable difunctional building blocks is synthesized by step growth polymerization. Step-growth polymerizations between CA and L-LDI are conducted at different loading ratios by mole ([CA]/[L-LDI] (n/n) = 1:1; 1:2 and 1:4) to investigate the effect on wettability, thermal, and biodegradable properties of final PURs. The intermediates and resulting PURs are characterized by Fourier transform infrared spectroscopy (FT-IR), water contact angle measurements (WCA), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Moreover, biodegradability of obtained PURs is also investigated by conducting enzymatic degradation experiments. The experimental results reveal that PURs having higher L-LDI loading exhibit higher hydrophobic and thermal properties, while lower biodegradable characteristic compared to others. Thus, it is clear that the obtained PURs have great potential for several applications particularly in the fields of drug delivery and tissue engineering requiring biodegradable properties. (C) 2019 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.polymdegradstab.2019.04.015
dc.identifier.endpage48en_US
dc.identifier.issn0141-3910
dc.identifier.issn1873-2321
dc.identifier.scopus2-s2.0-85064972865en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.1016/j.polymdegradstab.2019.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19104
dc.identifier.volume165en_US
dc.identifier.wosWOS:000473374500006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofPolymer Degradation And Stabilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiodegradable Polymersen_US
dc.subjectPolymer Synthesisen_US
dc.subjectPolyurethaneen_US
dc.subjectThermal Propertiesen_US
dc.subjectStep-Growth Polymerizationen_US
dc.subjectBile-Acidsen_US
dc.subjectCopolymersen_US
dc.subjectFoamsen_US
dc.subjectOilen_US
dc.subjectPoly(Epsilon-Caprolactone)en_US
dc.subjectLimoneneen_US
dc.subjectPolyolsen_US
dc.subjectLigninen_US
dc.titleSynthesis and characterization of biodegradable polyurethanes made from cholic acid and L-lysine diisocyanate ethyl esteren_US
dc.typeArticleen_US

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