InvestIgatIon of cyto-toxIcIty of an InnovatIve BIofactor Mta product In dIfferent huMan cells: a pIlot study

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dc.authorscopusid58512612700
dc.authorscopusid57297478900
dc.authorscopusid55317572200
dc.authorscopusid57202749454
dc.authorscopusid58513344000
dc.authorscopusid56954780800
dc.authorscopusid23004723200
dc.contributor.authorAkyol G.D.
dc.contributor.authorKolcu M.I.B.
dc.contributor.authorAlpaslan N.Z.
dc.contributor.authorTaşpınar F.
dc.contributor.authorMızrak R.Y.
dc.contributor.authorTunç S.K.
dc.contributor.authorİnanç B.
dc.date.accessioned2024-06-12T10:26:25Z
dc.date.available2024-06-12T10:26:25Z
dc.date.issued2023
dc.description.abstractIntroduction: Mineral trioxide aggregate (MTA) is one of the most popular and convenient material among current endodontic materials. In addition to MTA advantages, there are also features that need to be improved. Color stability and consistency are notorious concerns in MTA, and materials need improvement regarding theses aspects. There are companies, which work on these contents. Objectives: The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products. Material and methods: 3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to generate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cytotoxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests. Results: According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1: 1 and 1: 2 dilutions, they were not cyto-toxic in 1: 4 and 1: 8 dilutions. Conclusions: MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products. © 2023 Polish Dental Association.en_US
dc.description.sponsorshipThis study was supported by Van Yüzüncü Yıl University Scientific Project Presidency, with project number TSA-2018-6444.en_US
dc.identifier.doi10.5114/jos.2023.128770
dc.identifier.endpage76en_US
dc.identifier.issn0011-4553
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85166248483en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://doi.org/10.5114/jos.2023.128770
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16839
dc.identifier.volume76en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofJournal of Stomatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngelus Mta; Biodentine; Biofactor Mta; Cyto-Toxicity; Mtt Assayen_US
dc.titleInvestIgatIon of cyto-toxIcIty of an InnovatIve BIofactor Mta product In dIfferent huMan cells: a pIlot studyen_US
dc.typeArticleen_US

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