Degenerative changes of lumbar spine and their clinical implications in patients with axial spondyloarthritis

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dc.authoridKILIÇ, Erkan/0000-0003-4355-4356
dc.authoridKilic, Gamze/0000-0003-1998-0988
dc.authorwosidOzgocmen, Salih/K-9588-2015
dc.authorwosidKILIÇ, Erkan/AAW-5006-2020
dc.authorwosidKilic, Gamze/JVN-0719-2024
dc.contributor.authorKilic, Gamze
dc.contributor.authorSenol, Serkan
dc.contributor.authorBaspinar, Sevgi
dc.contributor.authorKilic, Erkan
dc.contributor.authorOzgocmen, Salih
dc.date.accessioned2024-06-12T10:51:47Z
dc.date.available2024-06-12T10:51:47Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe objective of this study was to assess degenerative changes (DCs) on magnetic resonance imaging (MRI) of lumbar spine in axial spondyloarthritis (axSpA) and non-specific mechanical low back pain (mLBP). Patients were consecutively recruited and all underwent MRI of the lumbar spine in this cross-sectional study. Disk degeneration (DD, Pfirrmann classification), endplate changes (Modic, types 1, 2, and 3), annular fissure, disk bulging, and protrusion or extrusion at each lumbar spinal level were assessed using anonymized images. Patients with axSpA were assessed for disease activity, functioning, and quality of life. Univariate and subsequent multivariate logistic regression analyses with adjustments of various covariates were used to assess association between MRI findings and clinical variables. One hundred twenty-three patients had non-radiographic (nr-axSpA) and 144 had radiographic axSpA/ankylosing spondylitis (AS). Degenerative changes were more prevalent in patients with mLBP (n = 105) than axSpA. Disk degeneration was the most prevalent MRI finding, followed by annular fissure, disk herniation (protrusion or extrusion), and Modic changes (MCs) in axSpA. Disk herniation was more prevalent in patients with nr-axSpA compared to AS. Modic changes (OR = 6.455), lumbar disk herniation (OR = 2.278), annular fissure (OR = 2.842), conventional synthetic or biologic disease-modifying antirheumatic drugs (csDMARDs) non-users (OR = 2.225), and advanced age (OR = 31.556) were factors associated with an increased risk of DD in axSpA. Coexisting DD increased the burden of disease in axSpA. A considerable proportion of patients with axSpA had DD at the lumbar spine. These degenerative changes might explain some of the complaints and should not been overlooked in patients with axSpA.en_US
dc.identifier.doi10.1007/s10067-022-06321-w
dc.identifier.endpage116en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue1en_US
dc.identifier.pmid35922576en_US
dc.identifier.scopus2-s2.0-85135341792en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-022-06321-w
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18484
dc.identifier.volume42en_US
dc.identifier.wosWOS:000835614600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectLow Back Painen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectLow-Back-Painen_US
dc.subjectDisc Degenerationen_US
dc.subjectDouble-Blinden_US
dc.subjectTnf-Alphaen_US
dc.subjectMrien_US
dc.subjectClassificationen_US
dc.subjectSpondylitisen_US
dc.subjectLesionsen_US
dc.subjectAdultsen_US
dc.titleDegenerative changes of lumbar spine and their clinical implications in patients with axial spondyloarthritisen_US
dc.typeArticleen_US

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