Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study

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dc.contributor.authorAltinok, A. Y.
dc.contributor.authorYildirim, S.
dc.contributor.authorAltug, T.
dc.contributor.authorSut, N.
dc.contributor.authorOber, A.
dc.contributor.authorOzsahin, E. M.
dc.contributor.authorAzria, D.
dc.date.accessioned2024-06-12T10:52:29Z
dc.date.available2024-06-12T10:52:29Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats. Materials and methods: 60 female wistar-albino rats were divided into 6 groups: Control (group A), RT alone (group B), RT + TAM (group C), RT + anastrozole (ANA group D), RT + LET (group E), and RT + exemestane (EXE, group F). RT consisted of 30 Gy in 10 fractions to both lungs with an anterior field at 2 cm depth. Equivalent doses for 60 kg adult dose per day of TAM, ANA, LET, and EXE were calculated according to the mean weight of rats and orally administrated with a feeding tube. Percentage of lung with fibrosis was quantified with image analysis of histological sections of the lung. The mean score values were calculated for each group. the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test. Results: Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2.2 for groups A, B, C, D, E, and F, respectively (p = 0.000). TAM increased RT-induced lung fibrosis but without statistical significance. Groups treated with RT + AI showed significantly less lung fibrosis than groups treated with RT alone or RT + TAM (p = 0.000). RT + AI groups showed nearly similar RT-induced lung fibrosis than control group. Conclusions: In this study, we found that AI decreased RT-induced lung fibrosis to the control group level suggesting protective effect. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.breast.2016.04.003
dc.identifier.endpage177en_US
dc.identifier.issn0960-9776
dc.identifier.issn1532-3080
dc.identifier.pmid27326979en_US
dc.identifier.scopus2-s2.0-84974831128en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.1016/j.breast.2016.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18723
dc.identifier.volume28en_US
dc.identifier.wosWOS:000379683300026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofBreasten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAromatase Inhibitorsen_US
dc.subjectRadiation Therapyen_US
dc.subjectRadioprotective Effecten_US
dc.subjectBreast Canceren_US
dc.subjectGrowth-Factor-Betaen_US
dc.subjectPulmonary-Fibrosisen_US
dc.subjectSystemic Therapyen_US
dc.subjectRadiotherapyen_US
dc.subjectTamoxifenen_US
dc.titleAromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental studyen_US
dc.typeArticleen_US

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