The effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms on the development of diabetic nephropathy in type 2 diabetes mellitus patients

Basit Öğe Kaydı
dc.authoridYukcu, Fulya/0000-0003-3468-2655
dc.authorwosidYukcu, Fulya/JUL-4219-2023
dc.contributor.authorYukcu, Fulya
dc.contributor.authorSipahi, Tammam
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorUstundag, Sedat
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:16:50Z
dc.date.available2024-06-12T11:16:50Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIMS: Diabetic nephropathy is one of the major complications of Type 2 diabetes mellitus. In this study, we aimed to investigate the effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms on the development of diabetic nephropathy in patients with type 2 diabetes mellitus. METHODS: This study included 100 type 2 diabetes mellitus patients with diabetic nephropathy patients (patient group) and 99 type 2 diabetes mellitus patients without diabetic nephropathy (control group). Polymerase chain reaction and restriction fragment length polymorphism methods were used to identify polymorphisms in the angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C genes.RESULTS: There was no significant difference in genotype frequencies of M235T gene polymorphism between patient and control groups (chi 2 = 4.01, df = 2, p = 0.13). There was no significant difference in genotype frequencies of T174M gene polymorphism between patient and control groups (X2 = 0.36, df = 2, p = 0.83). There was no significant difference in genotype frequencies of A1166C gene polymorphism between patient and control groups (chi 2 = 0.51, df = 2, p = 0.77).CONCLUSIONS: The results showed no significant difference in angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms between the patient and control groups. Future studies are needed to validate the results of this study and to explore underlying mechanisms (Tab. 3, Fig. 3, Ref. 35). Text in PDF www.elis.sken_US
dc.identifier.doi10.4149/BLL_2023_028
dc.identifier.endpage181en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3en_US
dc.identifier.pmid36598307en_US
dc.identifier.scopus2-s2.0-85147834472en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2023_028
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24477
dc.identifier.volume124en_US
dc.identifier.wosWOS:000944162900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectDiabetic Nephropathyen_US
dc.subjectAngiotensinogen Gene Polymorphismen_US
dc.subjectAngiotensin Type 1 Receptoren_US
dc.subjectGene Polymorphismen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectT174m Polymorphismen_US
dc.subjectConverting Enzymeen_US
dc.subjectAssociationen_US
dc.subjectSystemen_US
dc.subjectRisken_US
dc.subjectM235ten_US
dc.subjectI/Den_US
dc.titleThe effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms on the development of diabetic nephropathy in type 2 diabetes mellitus patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu