Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats

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dc.contributor.authorKanter, M
dc.contributor.authorCoskun, O
dc.contributor.authorKalayci, M
dc.contributor.authorBuyukbas, S
dc.contributor.authorCagavi, F
dc.date.accessioned2024-06-12T10:52:05Z
dc.date.available2024-06-12T10:52:05Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible beneficial effects of Nigella sativa (NS) in comparison to methylprednisolone on experimental spinal cord injury (SCI) in rats. SCI was performed by placing an aneurysm clip extradurally at the level of T11-12. Rats were neurologically tested over 24 h after trauma and spinal cord tissue samples were harvested for both biochemical and histopathological evaluation. The neurological scores of rats were not found to be different in SCI groups. SCI significantly increased the spinal cord tissue malondialdehyde (MDA) and protein carbonyl (PC) levels, however SCI decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities compared to the control. Methylprednisolone and NS treatment decreased tissue MDA and PC levels and prevented inhibition of SOD, GSH-Px and CAT enzymes in the tissues. The most significant results were obtained when NS was given. In SCI and placebo groups, the neurons of spinal cord tissue became extensively dark and degenerated with picnotic nuclei. The morphology of neurons in methylprednisolone and NS-treated groups were well protected, however, not as well as the neurons of the control group. The number of neurons in the spinal cord tissue of the SCI and placebo groups was significantly less than the control, laminectomy, methylprednisolone and NS-treated groups. In conclusion, NS treatment might be beneficial in spinal cord tissue damage, and therefore shows potential for clinical implications.en_US
dc.identifier.doi10.1191/0960327106ht608oa
dc.identifier.endpage133en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue3en_US
dc.identifier.pmid16634331en_US
dc.identifier.scopus2-s2.0-33645981973en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1191/0960327106ht608oa
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18586
dc.identifier.volume25en_US
dc.identifier.wosWOS:000236012200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectLipid Peroxidationen_US
dc.subjectMethyl-Prednisoloneen_US
dc.subjectNigella Sativaen_US
dc.subjectRaten_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectMethylprednisoloneen_US
dc.subjectCompressionen_US
dc.subjectOilen_US
dc.subjectMetabolismen_US
dc.subjectLeukocytesen_US
dc.subjectMelatoninen_US
dc.subjectNaloxoneen_US
dc.subjectL.en_US
dc.titleNeuroprotective effects of Nigella sativa on experimental spinal cord injury in ratsen_US
dc.typeArticleen_US

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