The prevention of propofol injection pain by tramadol or ondansetron

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dc.contributor.authorMemis, D
dc.contributor.authorTuran, A
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorKaya, G
dc.contributor.authorPamukçu, Z
dc.date.accessioned2024-06-12T10:51:35Z
dc.date.available2024-06-12T10:51:35Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objective: To compare the efficacy of tramadol and ondansetron in minimizing the pain due to injection of propofol in 100 patients. Methods: An intravenous cannula was inserted in the dorsum of the hand. After tourniquet application to the forearm, tramadol 50 mg (Group 1, n = 50) or ondansetron 4 mg (Group 2, n = 50) was injected. The tourniquet was released after 20 s, and propofol 5 mL was administered over 5 s. The patients were observed and asked if they had pain in the arm and the response was assessed. Nausea and vomiting and degree of sedation were recorded for the first postoperative 24 h. Results: Twenty-one patients in Group 1 and 14 patients in Group 2 reported no pain. Slight pain was seen in 15 patients in Group 1 and in 14 patients in Group 2. Moderate pain was seen in 10 patients in Group 1 and 15 patients in Group 2. Severe pain was seen in four of the patients in Group 1 and three patients in Group 2. There was no significant difference of pain between Groups 1 and 2, but we found a significant reduction of nausea and vomiting in the ondansetron group compared with the tramadol group (P = 0.033). Conclusions: Tramadol or ondansetron are equally effective in preventing pain from propofol injection. The added benefit of a reduction in nausea and vomiting after operation in the ondansetron group may be a reason to prefer this drug.en_US
dc.identifier.doi10.1017/S0265021502000078
dc.identifier.endpage51en_US
dc.identifier.issn0265-0215
dc.identifier.issn1365-2346
dc.identifier.issue1en_US
dc.identifier.pmid11913803en_US
dc.identifier.scopus2-s2.0-0036360872en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021502000078
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18403
dc.identifier.volume19en_US
dc.identifier.wosWOS:000173708900007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal Of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnaesthetics, Intravenous, Propofolen_US
dc.subjectAnalgesics, Opioid, Tramadolen_US
dc.subjectAnti-Emetics, Ondansetronen_US
dc.subjectSensation, Painen_US
dc.subjectPostoperative Nauseaen_US
dc.subjectPharmacologyen_US
dc.subjectEfficacyen_US
dc.subjectMetoclopramideen_US
dc.subjectLignocaineen_US
dc.subjectMechanismen_US
dc.subjectLidocaineen_US
dc.subject5-Ht3en_US
dc.titleThe prevention of propofol injection pain by tramadol or ondansetronen_US
dc.typeArticleen_US

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