Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats

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dc.authoridGuler, Eray Metin/0000-0003-4351-1719
dc.authoridTopcu, Gulacti/0000-0002-7946-6545
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridYILMAZ, ANIL/0000-0002-0704-6306
dc.authorwosidGuler, Eray Metin/T-6699-2017
dc.authorwosidTopcu, Gulacti/C-8344-2015
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorYilmaz, Anil
dc.contributor.authorUckaya, Fatih
dc.contributor.authorBayindir, Nihan
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorToprak, Ali
dc.contributor.authorKocyigit, Abdurrahim
dc.contributor.authorEsrefoglu, Mukaddes
dc.date.accessioned2024-06-12T10:51:59Z
dc.date.available2024-06-12T10:51:59Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractUlcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.en_US
dc.description.sponsorshipBezmialem Vakif University, Department of Scientific Research Projects [6.2014/28]en_US
dc.description.sponsorshipThis work was supported by Bezmialem Vakif University, Department of Scientific Research Projects [Project No: 6.2014/28]en_US
dc.identifier.doi10.1111/jfbc.14299
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue11en_US
dc.identifier.pmid35778816en_US
dc.identifier.scopus2-s2.0-85133181352en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/jfbc.14299
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18559
dc.identifier.volume46en_US
dc.identifier.wosWOS:000819668000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Inflammatory Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectAntiulcer Activityen_US
dc.subjectRosmarinus Officinalisen_US
dc.subjectToxicological Effectsen_US
dc.subjectUlcerative Colitisen_US
dc.subjectUrsolic Aciden_US
dc.subjectAntioxidant Propertiesen_US
dc.subjectMedicinal-Plantsen_US
dc.subjectAutomated-Methoden_US
dc.subjectRosemaryen_US
dc.subjectAssayen_US
dc.subjectProtectionen_US
dc.subjectExtractsen_US
dc.subjectL.en_US
dc.titleComparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in ratsen_US
dc.typeArticleen_US

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