Optimization of Ultrasonic Extraction of Nutraceutical and Pharmaceutical Compounds from Bee Pollen with Deep Eutectic Solvents Using Response Surface Methodology

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dc.authoridBayram, Sinan/0000-0002-2156-1566
dc.authoridKutlu, Naciye/0000-0002-4075-8823
dc.authoridPandiselvam, R./0000-0003-0996-8328
dc.authoridCelik, Saffet/0000-0002-4225-2471
dc.authoridGERCEK, YUSUF CAN/0000-0001-5372-0229
dc.authorwosidBayram, Sinan/AAB-4949-2021
dc.authorwosidGercek, Yusuf Can/AAC-8693-2020
dc.authorwosidKutlu, Naciye/K-4265-2017
dc.authorwosidPandiselvam, R./I-5229-2019
dc.authorwosidCelik, Saffet/R-9630-2017
dc.contributor.authorCelik, Saffet
dc.contributor.authorKutlu, Naciye
dc.contributor.authorGercek, Yusuf Can
dc.contributor.authorBayram, Sinan
dc.contributor.authorPandiselvam, Ravi
dc.contributor.authorBayram, Nesrin Ecem
dc.date.accessioned2024-06-12T10:54:20Z
dc.date.available2024-06-12T10:54:20Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn recent years, there has been increasing interest in green extraction methods and green solvents due to their many advantages. In this study, the effects of an ultrasonic extraction method and deep eutectic solvents (DESs) on the extraction of different bioactive substances from bee pollen were investigated. In this regard, the effects of process variables such as the molar ratio of the DES (1, 1.5, and 2), sonication time (15, 30, and 45 min), and ultrasonic power (90, 135 and 180 W) on total individual amino acids, total individual organic acids, and total individual phenolic compounds were investigated by response surface methodology (RSM). The optimal conditions were found to be a molar ratio of 2, sonication time of 45 min, and ultrasonic power of 180 W (R-2 = 0.84). Extracts obtained via the maceration method using ethanol as a solvent were evaluated as the control group. Compared with the control group, the total individual amino acid and total individual organic acid values were higher using DESs. In addition, compounds such as myricetin, kaempferol, and quercetin were extracted at higher concentrations using DESs compared to controls. The results obtained in antimicrobial activity tests showed that the DES groups had broad-spectrum antibacterial effects against all bacterial samples, without exception. However, in yeast-like fungus samples, this inhibition effect was negligibly low. This study is the first to evaluate the impact of DESs on the extraction of bioactive substances from bee pollen. The obtained results show that this innovative and green extraction technique/solvent (ultrasonic extraction/DES) can be used successfully to obtain important bioactive compounds from bee pollen.en_US
dc.identifier.doi10.3390/foods11223652
dc.identifier.issn2304-8158
dc.identifier.issue22en_US
dc.identifier.pmid36429245en_US
dc.identifier.scopus2-s2.0-85142514574en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/foods11223652
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18992
dc.identifier.volume11en_US
dc.identifier.wosWOS:000887224000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofFoodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBee Pollenen_US
dc.subjectOptimizationen_US
dc.subjectGreen Extractionen_US
dc.subjectGreen Solventen_US
dc.subjectAntioxidant Activityen_US
dc.subjectAssisted Extractionen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectAmino-Acidsen_US
dc.subjectCytotoxicityen_US
dc.subjectPolyphenolsen_US
dc.subjectOriginen_US
dc.subjectHoneyen_US
dc.titleOptimization of Ultrasonic Extraction of Nutraceutical and Pharmaceutical Compounds from Bee Pollen with Deep Eutectic Solvents Using Response Surface Methodologyen_US
dc.typeArticleen_US

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