The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns

Simple item page
dc.authoridCanda, M. Tunc/0000-0001-6348-4493;
dc.authorwosidCanda, M. Tunc/ABC-5001-2020
dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorSayam, N. Cenk
dc.contributor.authorCanda, M. Tunc
dc.contributor.authorAhmet, Newze
dc.contributor.authorArda, Sezer
dc.contributor.authorSuet, Necdet
dc.contributor.authorVarol, Fuesun G.
dc.date.accessioned2024-06-12T11:16:46Z
dc.date.available2024-06-12T11:16:46Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description6th International Congress of the Turkish-German-Gynecological-Association -- MAY 19-22, 2005 -- Antalya, TURKEYen_US
dc.description.abstractObjective This study was designed to investigate the relationship between the second trimester maternal serum markers and adverse pregnancy outcomes in healthy newborns. Materials and methods A total of 749 women who delivered in our institution with complete follow up and second-trimester triple marker test data available were included in the study. Women with multiple pregnancies, chronic diseases, diabetes mellitus, obesity, smokers and infants with chromosomal and congenital abnormalities were excluded. Maternal serum alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG) and unconjugated estriol (uE(3)) values were investigated in our cohort who developed preeclampsia (n = 28), gestational diabetes (GM) (n = 69), preterm labor-birth (n = 100), oligohydramnios n = 37) and macrosomia (n = 59) by using receiver operating characteristic (ROC) curve analysis, with chi-square and Pearson's correlation tests. Results Women with uE(3) <= 1.26 MoM (P = 0.001, AUC = 0.666), HCG > 1.04 MoM (P = 0.032, AUC = 0.599) or AFP <= 0.69 MoM (P = 0.049, AUC = 0.600) values significantly developed oligohydramnios. Also, macrosomic infants were observed in women who had HCG values > 0.86 MoM (P = 0.047, AUC = 0.578). Patients with HCG > 1.04 MoM (P = 0.04, AUC = 0.565) and uE(3) <= 0.88 MoM (P = 0.049, AUC = 0.571) developed GDM. HCG levels, 2.5 or, 3 MoM were significantly associated with the development of oligohydramnios [P = 0.005; OR = 4 (95% CI: 1.7-9.7)], [P = 0.008; OR = 4.9 (95% CI: 1.7-13.7)], respectively. When women with adverse (n = 237) and normal (n = 512) outcomes were compared there were significant differences in maternal serum AFP (1.40 +/- 0.84 vs. 1.23 +/- 0.75 MoM, P = 0.006) and uE(3) values (1.38 +/- 1.42 vs. 1.45 +/- 0.98 MoM, P = 0.001). Conclusions Serum estriol, AFP or HCG values in triple test results may be associated with development of oligohydramnios, gestational diabetes and macrosomia in women with healthy and normal appearing fetuses.en_US
dc.description.sponsorshipTurkish German Gynecol Assocen_US
dc.identifier.doi10.1007/s00404-007-0421-6
dc.identifier.endpage53en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue1en_US
dc.identifier.pmid17653738en_US
dc.identifier.scopus2-s2.0-36348934517en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-007-0421-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24453
dc.identifier.volume277en_US
dc.identifier.wosWOS:000252662200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTurkish Populationen_US
dc.subjectTriple Testen_US
dc.subjectPerinatal Outcomeen_US
dc.subjectHuman Chorionic-Gonadotropinen_US
dc.subjectSerum Alpha-Fetoproteinen_US
dc.subjectLow Unconjugated Estriolen_US
dc.subject2nd Trimesteren_US
dc.subjectBiochemical Markersen_US
dc.subjectDown-Syndromeen_US
dc.subjectComplicationsen_US
dc.subjectScreenen_US
dc.subjectAbsenceen_US
dc.subjectWomenen_US
dc.titleThe association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newbornsen_US
dc.typeConference Objecten_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize