Tyrosine kinase-2 gene polymorphisms are associated with ulcerative colitis and Crohn's disease in Turkish Population

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dc.authoridCan, Hatice/0000-0002-6054-9244
dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridTezel, Ahmet/0000-0002-3054-475X
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidCan, Hatice/ABI-7678-2020
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidCAN, GÜRAY/AAA-3274-2020
dc.contributor.authorCan, Guray
dc.contributor.authorTezel, Ahmet
dc.contributor.authorGurkan, Hakan
dc.contributor.authorCan, Hatice
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorUnsal, Gulbin
dc.contributor.authorSoylu, Ali Riza
dc.date.accessioned2024-06-12T11:19:11Z
dc.date.available2024-06-12T11:19:11Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objective: Inflammatory bowel disease is a group of chronic inflammatory conditions affecting gastrointestinal tract. Lots of genes have been identified resulting in susceptibility to inflammatory bowel disease. Any polymorphism leading to functional modifications in tyrosine kinase-2 may precipitate excessive immune response in the intestinal mucosa. The aim of our study is to investigate the involvement of tyrosine kinase-2 polymorphisms in the patients with inflammatory bowel disease in Turkish population. Methods: Four single nucleotide polymorphisms in tyrosine kinase-2 (rs280523, rs2304256, rs280519 and rs280496) were genotyped in 60 Crohn's disease, 151 ulcerative colitis patients and 89 unrelated healthy controls. These polymorphisms were detected by real-time polymerase chain reaction. Results: The presence of genotype (CC) in rs2304256 and (AA) in rs280519 were found to increase the susceptibility to ulcerative colitis (P = 0.024, 0.025, respectively). rs2304256 (CA) and rs280519 (AG) have provided protection against ulcerative colitis (P = 0.021, 0.012, respectively). rs280519 (AG) was protective against Crohn's disease (P = 0.045). rs2304256 (CC) increased the susceptibility to inflammatory Crohn's disease (P = 0.014). The presence of rs2304256 (A) increased the susceptibility to perianal Crohn's disease (P = 0.03). Both rs280519 and rs2304256 polymorphisms were associated with the requirement of corticosteroid and immunosuppressive therapy in ulcerative colitis. Conclusion: This study is the first demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population. They may be effective in the etiology of inflammatory bowel disease in our population. Disparity between our study and others may be related to ethnic differences. (C) 2015 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipScientific Investigation Support Committee of Trakya University (TUBAP), Edirne, Turkey [TUBAP-2013/18]en_US
dc.description.sponsorshipthe project was financially supported by fund from the Scientific Investigation Support Committee of Trakya University (TUBAP), Edirne, Turkey (TUBAP-2013/18).en_US
dc.identifier.doi10.1016/j.clinre.2015.01.005
dc.identifier.endpage498en_US
dc.identifier.issn2210-7401
dc.identifier.issn2210-741X
dc.identifier.issue4en_US
dc.identifier.pmid25744728en_US
dc.identifier.scopus2-s2.0-84940893678en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinre.2015.01.005
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25094
dc.identifier.volume39en_US
dc.identifier.wosWOS:000360923500016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corp Offen_US
dc.relation.ispartofClinics And Research In Hepatology And Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammatory-Bowel-Diseaseen_US
dc.subjectPathogenesisen_US
dc.subjectLocien_US
dc.subjectSusceptibilityen_US
dc.subjectVariantsen_US
dc.subjectMultipleen_US
dc.subjectTyk2en_US
dc.titleTyrosine kinase-2 gene polymorphisms are associated with ulcerative colitis and Crohn's disease in Turkish Populationen_US
dc.typeArticleen_US

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