Biological activity screening of some hydrazone and chalcone derivatives

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dc.authorscopusid56094441300
dc.authorscopusid23034973800
dc.authorscopusid24757862800
dc.authorscopusid56098504600
dc.contributor.authorAKSÖZ B.E.
dc.contributor.authorONURDAĞ F.K.
dc.contributor.authorAKSÖZ E.
dc.contributor.authorÖZGACAR S.Ö.
dc.date.accessioned2024-06-12T10:26:36Z
dc.date.available2024-06-12T10:26:36Z
dc.date.issued2021
dc.description.abstractObjective: Today, the development of resistance to antibiotics is increasing rapidly. Loss of antibiotics effectiveness due to the development of resistance causes serious hazards. Especially methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis create life-threatening conditions in patients with a weak immune system. For this reason, it is important to develop new drug active substances against these microorganisms. In this article, hydrazones and chalcones were synthesized and some biological activities of these compounds such as antimicrobial and antituberculosis were investigated. This study was conducted to investigate new antimicrobial and antituberculous drug-active substances instead of antibiotics that lost their effectiveness due to the rapidly increasing resistance to existing antibiotics. Methods: The compounds were obtained by synthesis of chalcones via Claisen Schmidt condensation and then by reacting these chalcones with hydrazides to form hydrazone. Antimicrobial and antituberculosis activities of the compounds were evaluated by microdilution method and microplate alamar blue assays, respectively. Results: All compounds displayed the same activity against Mycobacterium tuberculosis (MIC: 64 ?g/mL). E4, 4'-Bromo-4-methyl chalcone, displayed the best activity against Meticilline resistant-Staphylococcus aureus (MIC: 16 ?g/mL). The most effective compounds against Enterococcus faecalis isolate and Enterococcus faecalis were found B26 (N-(1-(4fluorophenyl)-3-p-tolylallylidene)thiophene-2-carbohydrazide) and E8 (4'-fluoro-3-methyl chalcone), respectively (MIC: 32 ?g/mL). Conclusion: Hydrazones have been found to be more effective than chalcones against S. aureus ATCC 29213. However, chalcones exhibited a remarkable effect against meticilline resistant-Staphylococcus aureus and Enterococcus faecalis. In terms of tuberculosis bacillus, it did not differ whether the compounds had a chalcone or hydrazone structure. Both chalcones and hydrazones exhibited the same activity against candida species. All compounds were observed to be more effective than gentamicin against methicillin-resistant Staphylococcus aureus. © 2021, Turk Hijyen ve Deneysel Biyoloji Dergisi. All Rights Reserved.en_US
dc.identifier.doi10.5505/TurkHijyen.2020.02439
dc.identifier.endpage166en_US
dc.identifier.issn0377-9777
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85110742464en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage159en_US
dc.identifier.trdizinid490538en_US
dc.identifier.urihttps://doi.org/10.5505/TurkHijyen.2020.02439
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/490538
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16920
dc.identifier.volume78en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherRefik Saydam National Public Health Agency (RSNPHA)en_US
dc.relation.ispartofTurk Hijyen ve Deneysel Biyoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial; Antitubercular; Chalcone; Hydrazone; Microbial Resistanceen_US
dc.titleBiological activity screening of some hydrazone and chalcone derivativesen_US
dc.title.alternativeBazı hidrazon ve kalkon türevlerinin biyolojik aktivite taramasıen_US
dc.typeArticleen_US

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