Effect of topically applied povidone-iodine on transient evoked otoacoustic emissions in guinea pigs

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dc.authoridTas, Abdullah/0000-0002-5689-087X
dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authorwosidUZUN, CEM/K-3307-2012
dc.contributor.authorYagiz, R
dc.contributor.authorTas, A
dc.contributor.authorUzun, C
dc.contributor.authorAdall, MK
dc.contributor.authorKoten, M
dc.contributor.authorKarasalihoglu, AR
dc.date.accessioned2024-06-12T10:51:59Z
dc.date.available2024-06-12T10:51:59Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe possible cochlear toxicity of topically applied povidone-iodine solution was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOAEs). Seven adult pigmented guinea pigs (14 ears) with a normal acoustic pinna reflex were used. After the baseline TEOAE measurements, 0.1 mL of povidone-iodine solution was applied transtympanically into the middle ear in the study group. Saline solution and gentamicin were used as negative and positive control, respectively. TEOAE measurements were repeated on the 10th day, and four weeks after the first application. Tympanometric measurements were also carried out for both ears of all animals at the end of the study. Responses in all ears, which had povidone-iodine applied to them, disappeared in a way similar to those recorded in gentamicin-treated ears. Tympanometric measurements at the end of the study showed 'type A' tympanograms in all ears of all animals. The present study showed that povidone-iodine could have a cochleotoxic effect in guinea pigs. A study in humans with TEOAE before and after middle-ear surgery, where povidone-iodine can reach into the middle-ear cavity, may be useful for evaluating this result for clinical practice.en_US
dc.identifier.doi10.1258/002221503322334512
dc.identifier.endpage703en_US
dc.identifier.issn0022-2151
dc.identifier.issue9en_US
dc.identifier.pmid14561356en_US
dc.identifier.scopus2-s2.0-0142025327en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage700en_US
dc.identifier.urihttps://doi.org/10.1258/002221503322334512
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18558
dc.identifier.volume117en_US
dc.identifier.wosWOS:000185989300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHeadley Brothers Ltden_US
dc.relation.ispartofJournal Of Laryngology And Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Infective Agentsen_US
dc.subjectPovidone-Iodineen_US
dc.subjectCochleaen_US
dc.subjectOtoacoustic Emissionsen_US
dc.subjectSpontaneousen_US
dc.subjectOtotoxicityen_US
dc.subjectAntisepticsen_US
dc.titleEffect of topically applied povidone-iodine on transient evoked otoacoustic emissions in guinea pigsen_US
dc.typeArticleen_US

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