The Effect of Intravenous Pantoprazole and Ranitidine for Improving Preoperative Gastric Fluid Properties in Adults Undergoing Elective Surgery

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dc.authorscopusid7003369853
dc.authorscopusid7004533485
dc.authorscopusid7003311524
dc.authorscopusid57500102200
dc.authorscopusid55882854000
dc.authorscopusid6701467427
dc.contributor.authorMemiş D.
dc.contributor.authorTuran A.
dc.contributor.authorKaramanlioglu B.
dc.contributor.authorSaral P.
dc.contributor.authorTüre M.
dc.contributor.authorPamukçu Z.
dc.date.accessioned2024-06-12T10:27:55Z
dc.date.available2024-06-12T10:27:55Z
dc.date.issued2003
dc.description.abstractWe studied pantoprazole, a new potent and fast-acting proton pump inhibitor. Its effects on preoperative gastric fluid volume and pH have not yet been determined. In this randomized, controlled trial, we examined the effects of preoperative IV pantoprazole or ranitidine on gastric pH and volume. Ninety patients (ASA status I and II, scheduled for elective surgery) were studied. One hour before surgery, patients in Group I (n = 30) were given IV saline 5 mL, those in Group II (n = 30) were given 40 mg of pantoprazole IV, and those in Group III (n = 30) were given 50 mg of ranitidine IV. A nasogastric tube was inserted immediately after anesthesia induction. Gastric contents were aspirated, and volume and pH were recorded. The pH values determined in Group I were 3.73 ± 0.82; in Group II, they were 5.30 ± 1.84; and in Group III, they were 4.80 ± 1.40. There was no statistical difference between Groups 2 and 3, but there was a significant difference between Group I and Groups 2 and 3 (P < 0.0005). The volume of the gastric contents was 28. 67 ± 10.98 mL in Group I, 15.20 ± 15.52 mL in Group II, and 7.77 ± 11.17 mL in Group III. There was no statistical difference between Groups 2 and 3, but there was a statistically significant difference between Group I and Groups 2 and 3 (P < 0.0005). The proportion of patients considered "at risk" of significant lung injury should aspiration occur was 20% of Group I, 10% of Group II, and 3.3% of Group III. When statistically evaluated, there was no difference among groups. We concluded that the administration of IV pantoprazole and ranitidine 1 h before surgery is effective in reducing gastric pH and volume.en_US
dc.identifier.endpage1363en_US
dc.identifier.issn0003-2999
dc.identifier.issue5en_US
dc.identifier.pmid14570652en_US
dc.identifier.scopus2-s2.0-0142181282en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1360en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16974
dc.identifier.volume97en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofAnesthesia and Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPantoprazole; Pantpas; Proton Pump Inhibitor; Ranitab; Ranitidine; Adult; Aged; Anesthesia Induction; Article; Aspiration Pneumonia; Clinical Trial; Controlled Clinical Trial; Controlled Study; Double Blind Procedure; Elective Surgery; Female; Helicobacter Pylori; Human; Lung Injury; Major Clinical Study; Male; Nasogastric Tube; Preoperative Care; Priority Journal; Randomized Controlled Trial; Statistical Analysis; Stomach Acid Secretion; Stomach Juice; Stomach Ph; 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Benzimidazoles; Double-Blind Method; Female; Gastric Acid; Gastric Acidity Determination; Humans; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Middle Aged; Omeprazole; Pneumonia, Aspiration; Postoperative Period; Ranitidine; Risk Assessment; Stomach; Sulfoxidesen_US
dc.titleThe Effect of Intravenous Pantoprazole and Ranitidine for Improving Preoperative Gastric Fluid Properties in Adults Undergoing Elective Surgeryen_US
dc.typeArticleen_US

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