Iron deficiency and hematinic deficiencies in atrial fibrillation: A new insight into comorbidities

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dc.authoridURAL, DILEK/0000-0003-0224-1433
dc.authorwosidUral, Dilek/HMV-0020-2023
dc.authorwosidkozan, omer/ABC-9349-2021
dc.authorwosidaltay, servet/C-1387-2018
dc.authorwosidKeskin, Muhammed/W-8229-2018
dc.contributor.authorKeskin, Muhammed
dc.contributor.authorUral, Dilek
dc.contributor.authorAltay, Servet
dc.contributor.authorArgan, Onur
dc.contributor.authorBorklu, Edibe Betul
dc.contributor.authorKozan, Omer
dc.date.accessioned2024-06-12T10:52:49Z
dc.date.available2024-06-12T10:52:49Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Iron deficiency (ID) is the most common nutritional deficiency, and iron metabolism becomes further deteriorated in the presence of certain conditions, such as heart failure (HF). Atrial fibrillation (AF) has many similarities to HF, including a chronic inflammatory pathophysiology; however, the prevalence of ID and other hematinic deficiencies in AF patients have not been determined. Methods: In this study, the prevalence of iron (serum ferritin < 100 mu g/L or ferritin 100-299 mu g/L with transferrin saturation < 20%), vitamin B12 (< 200 pg/mL), and folate deficiency (< 4.0 ng/mL) was evaluated in 101 patients with non-valvular AF with preserved left ventricular ejection fraction and no signs of HF, and the results were compared with 35 age-and gender-matched controls. Results: Anemia was detected in 26% of the patients. A total of 48 (47.6%) patients had ID, 10 (9.9%) had a vitamin B12 deficiency, and 13 (12.9%) had a folate deficiency. The prevalence of ID was similar in the controls and the paroxysmal AF patients, but increased gradually in persistent and permanent AF. Univariate logistic regression analysis demonstrated that permanent vs. paroxysmal AF [Odds ratio (OR): 2.17; 95% confidence interval (CI): 0.82-5.69; p=0.011], high sensitive Creactive protein (OR: 1.47; 95% CI: 0.93-2.36; p=0.019), N-terminal pro b-type natriuretic peptide (OR: 1.24; 95% CI: 0.96-1.71; p=0.034), and white blood cell count (OR: 1.21; 95% CI: 0.95-1.58; p=0.041) were associated with ID. In multivariable analysis, permanent AF remained as an independent clinical associate of ID (OR: 4.30; 95% CI: 0.83-12.07; p=0.039). Conclusion: ID is common in permanent AF, as in HF. Inflammation and neurohormonal activation seem to contribute to its development.en_US
dc.identifier.doi10.5543/tkda.2018.51001
dc.identifier.endpage110en_US
dc.identifier.issn1016-5169
dc.identifier.issue2en_US
dc.identifier.pmid29512626en_US
dc.identifier.scopus2-s2.0-85043287596en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage103en_US
dc.identifier.trdizinid347631en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2018.51001
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/347631
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18845
dc.identifier.volume46en_US
dc.identifier.wosWOS:000429379500004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectInflammationen_US
dc.subjectIron Deficiencyen_US
dc.subjectHeart-Failureen_US
dc.subjectInflammatory Pathwaysen_US
dc.subjectAnemiaen_US
dc.subjectMarkersen_US
dc.titleIron deficiency and hematinic deficiencies in atrial fibrillation: A new insight into comorbiditiesen_US
dc.typeArticleen_US

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