Effect of aminophylline on recovery from sevoflurane anaesthesia

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dc.authoridColak, Alkin/0000-0001-9103-4844
dc.authorwosidColak, Alkin/R-8739-2017
dc.contributor.authorTuran, A
dc.contributor.authorMemis, D
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorÇolak, A
dc.contributor.authorPamukçu, Z
dc.contributor.authorTuran, N
dc.date.accessioned2024-06-12T10:51:35Z
dc.date.available2024-06-12T10:51:35Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objective: In this randomized, double-blind study, we aimed to investigate the effect of aminophylline on recovery from sevoflurane. Methods: One-hundred ASA I-II patients scheduled for elective surgery were randomly divided into two groups receiving either NaCl 0.9% (Group 1, n = 50) or aminophylline 5 mg kg(-1) (Group 2, n = 50). All patients were premedicated with atropine 0.01 mg kg(-1) and midazolam 0.06 mg kg(-1) intramuscularly. Anaesthesia was induced with propofol 2 mg kg(-1) for muscle relaxation, and atracurium 0.5 mg kg(-1) was maintained with sevoflurane 2% in 50% oxygen and nitrous oxide. Further atracurium (0.1 mg kg(-1)) was given when needed. Aminophylline or saline was given after sevoflurane was discontinued. Heart rate, mean arterial pressure, peripheral oxygen saturation, the duration of anaesthesia and recovery times (eye opening, verbal response, extubation and successful performance of arithmetical calculations) were recorded. Results: There were no statistically significant differences in mean arterial pressure, peripheral oxygen saturation and anaesthesia time between the two groups. Heart rate increased significantly (P < 0.05) after aminophylline and was also higher than in the placebo group. Recovery times were significantly shorter (P < 0.001) in the patients receiving aminophylline. Conclusions: Aminophylline speeded recovery after sevoflurane anaesthesia and it may have some advantage in anaesthesia practice for patients.en_US
dc.identifier.doi10.1017/S0265021502000728
dc.identifier.endpage454en_US
dc.identifier.issn0265-0215
dc.identifier.issn1365-2346
dc.identifier.issue6en_US
dc.identifier.pmid12094921en_US
dc.identifier.scopus2-s2.0-0036617081en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage452en_US
dc.identifier.urihttps://doi.org/10.1017/S0265021502000728
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18402
dc.identifier.volume19en_US
dc.identifier.wosWOS:000176911200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEuropean Journal Of Anaesthesiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnaesthetics, Inhalation, Sevofluraneen_US
dc.subjectPostoperative Period, Anaesthesia Recovery Perioden_US
dc.subjectXanthines, Theophylline, Aminophyllineen_US
dc.subjectIsofluraneen_US
dc.subjectAdenosineen_US
dc.titleEffect of aminophylline on recovery from sevoflurane anaesthesiaen_US
dc.typeArticleen_US

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